The current state of medication shortages is a significant concern globally, with the US experiencing a record 323 drug shortages in the first three months of 2024, affecting at least half a million patients on average per shortage.

The most common causes of medication shortages are manufacturing and quality problems, as well as supply chain gaps and downtime, which can lead to prolonged disruptions in patient care.

The average shortage lasts over two years, and the lack of transparency in the pharmaceutical industry hinders the response to shortages, making it challenging for healthcare systems to address the problem effectively.

In the US, the FDA has reported 111 drug shortages, and pharmacies face critical prescription drug shortages, particularly for medications such as Adderall, which is used to treat ADHD.

The FDA works with manufacturers to address drug shortages, but production problems and quality issues contribute to the shortages, and the suspension of production can lead to shortages.

To manage potential medication shortages and find alternative solutions, it is essential to work closely with healthcare providers and pharmacists, who can help identify potential shortages and provide guidance on alternative medications.

Patients can explore alternative medications, such as Vyvanse, if their regular medication, like Adderall, is unavailable due to shortages.

Pharmacists collaborate with providers to find alternative strengths and dosage changes that can help patients during medication shortages.

Checking the national drug shortage list can help find alternatives, and refilling prescriptions early can also help avoid shortages.

Websites like GoodRX can help find the cheapest medication options, and coupons and programs can reduce prescription costs significantly.

However, without knowing the specific medications your parent is taking, it is impossible to determine if they are currently in short supply or at risk of shortage.

It is crucial to consult with your parent's healthcare provider and pharmacist to discuss potential shortages and alternative solutions, as they can provide personalized guidance and support.

Additionally, staying informed about medication shortages through reputable sources, such as the FDA website, can help you stay up-to-date on the latest information and make informed decisions about your parent's care.

By working together with healthcare providers and staying informed, you can help ensure that your parent receives the necessary medications and care to manage their chronic conditions effectively.

The FDA data shows that 90 percent of prescriptions are for generic drugs, and most prescription drugs in shortages are generic options.

Prescription drug shortages are linked to manufacturing and quality problems, as well as delays and discontinuations.

The FDA announced a shortage of Adderall due to manufacturing delays, and Teva experienced ongoing intermittent manufacturing delays.

Demand for Adderall rose nearly 27% in recent years, and eight manufacturers reported Adderall shortages to the FDA.

Supply chain disruptions can cause medication shortages, and lack of transparency hinders solutions to medication shortages.

The FDA works with manufacturers to understand and mitigate shortages, and manufacturing delays and demand increases can cause shortages.

To develop a plan for managing potential medication shortages and finding alternative solutions, it is essential to stay informed about the current state of medication shortages and work closely with healthcare providers and pharmacists.

By doing so, you can help ensure that your parent receives the necessary medications and care to manage their chronic conditions effectively, even in the face of medication shortages.

The current state of medication shortages is a significant concern globally, with the US experiencing a record 323 drug shortages in the first three months of 2024, affecting at least half a million patients on average per shortage.

Title:

Content: General Supervision
Elham Aboul Fath
Editor-in-Chief
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General Supervision
Elham Aboul Fath
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Thank you for your patience.
An Unexpected Catastrophe in the World ’ s Largest Country: The Complete Story of U.S. Drug Shortages
The deficit is at a record level.
According to data from the American Society of Health System Pharmacists and the University of Utah Drug Information Service, organizations began tracking drug shortages for the first time in 2001. Steady since 2021 – now reaching a record high of 323 drugs in the first three months of 2024.
Paul Abramowitz, CEO of the American Society of Health System Pharmacists, wrote in a blog post on Thursday: “It ’ s been a long time to end drug shortages, ” and wrote:“ All drug classes are vulnerable to shortages, some of the most worrisome shortages include sterile injectable generic drugs, including cancer chemotherapy drugs and emergency drugs stored in hospital vans and procedural areas. It is dangerous for doctors and patients. ”
In addition to the 32 chemotherapy drugs that are deficient, the five categories of drugs with the greatest deficiency include central nervous system stimulants, antimicrobials, hormonal agents, and intravenous fluids. [1] The Drug Deficiency Database maintained by the American Society of Health System Pharmacists and the University of Utah is based on voluntary reports from practitioners, patients, and others that have been confirmed by manufacturers. The U.S. drug is in short supply, because it captures broader effects on service providers and patients.
The crisis has lasted a year and a half.
More than half of the treatment shortages have lasted for more than two years, according to an analysis by health consultancy IQVIA, and the average shortage affects at least half a million patients, many of them elderly, according to the US Office of Health and Human Services under the Assistant Secretary for Planning and Evaluation, which shared its analysis with Congress in May.
Growing demand can play a role in drug shortages, as with the recent shortage of weight-loss drugs, but often manufacturing and quality problems, such as supply chain gaps and downtime, are the root cause. And varied.
But the American Society of Health System Pharmacists has “serious concerns ” about parts of this proposal, especially financial sanctions imposed on hospitals that lack the resources to comply with the recommendations, Abramowitz wrote:“ We all know that managing shortages is not enough and is not a sustainable solution to the worsening crisis, and there is still a lot of work to be done at the federal level to fix the root causes of drug shortages. ”
Why Shortage Occurs
Shortages can be caused by high demand, as with the recent shortage of weight-loss drugs, but this is not usually the main problem.
The FDA also blames manufacturing and quality problems, supply chain gaps, and downtime, and Dr. Emily Tucker, a drug shortage expert and an assistant professor of industrial engineering at Clemson University, says that when there is an indication of shortages, large health systems often also proactively place large orders, adding to the system ’ s stress.
“I don ’ t blame anyone.
“When I talk to all the stakeholders – whether it ’ s wholesalers, manufacturers, or the government – everyone wants this problem to end, ” she said.
Lack of transparency
Dr. Julie Grallo, chief medical officer and executive vice president of the American Society of Clinical Oncology, told the House Committee earlier that the shortage puts providers in a terrible position: “The drug shortage crisis is forcing providers to make impossible choices, and it is also hindering the development of new drugs. Health drugs are purchased only on a price basis, and manufacturers do not have to disclose the source of their acquisition of the ingredients.
The shortage of this generic chemical drug came due to the closure of one factory in India that manufactures the active ingredient after a surprise FDA inspection found “significant quality issues, ” says Jarallo:“ We didn ’ t know, and there was no transparency regarding the company ’ s supply of the majority of active pharmaceutical ingredients to all manufacturers across the board.
Knowing this in advance, we could have responded much faster, ” Dr. Steven Schundlemeyer, director of the PRIME Institute of the University of Minnesota School of Pharmacy, which focuses on economic and management issues, told the committee that as with defense contractors in the United States, New Zealand requires manufacturers to disclose their suppliers, and that information is required.
Easily accessible in the database.
Related Topics

The most common causes of medication shortages are manufacturing and quality problems, as well as supply chain gaps and downtime, which can lead to prolonged disruptions in patient care.

The average shortage lasts over two years, and the lack of transparency in the pharmaceutical industry hinders the response to shortages, making it challenging for healthcare systems to address the problem effectively.

In the US, the FDA has reported 111 drug shortages, and pharmacies face critical prescription drug shortages, particularly for medications such as Adderall, which is used to treat ADHD.

Title:

Content: US supply chain crisis continues, FDA points to 111 drug shortages
Global Social Hotspot 16: 35 2021 / 12 / 05
Share:
The supply chain crisis in the United States continues, and many goods are facing shortages.
The US media said that the US pharmacies have a number of critical prescription drugs in stock. The US Food and Drug Administration (FDA) pointed out that about 111 drugs are out of stock in the United States. The FDA stressed that it will continue to take measures to monitor the supply chain.
【 Omicron variant 】 Travellers must have a negative test within 48 hours for entering the United Kingdom 【 Next 】
The Federal Reserve warned on Wednesday that large parts of the United States had begun to be affected by supply chain disruptions and labor shortages last month.
According to the FDA website, 111 drugs are out of stock in the United States, including the heart disease drug digoxin injection, the chemical drug Dacarbazine and some antibiotics.
The authorities say there are many reasons for the shortage, including production problems, quality problems, drugs and even the suspension of production.
According to the FDA, about 80% of the manufacturers of active pharmaceutical ingredients are located overseas, and the manufacturers have provided the FDA with most of the drug shortage information.
The Administration will also work closely with these manufacturers to address the drug shortage.
【 Omicron variant 】 Study: Omicron carries a cold virus gene or helps avoid the immune system 【 Next 】
Long Island Newspaper Newsday quoted Tom D'Angelo, president of the New York State Association of Pharmacists, as saying the shipping of a large number of medicines, including those for common blood pressure and for the treatment of colds and flu, was blocked.
Because of supply chain problems, the owner of a New York drugstore said there were fewer brands for some drugs, including Ibuprofen.
The National Association of Community Pharmacists (NCPA) released a survey last month that found that most non-chain pharmacies are struggling to fill employee vacancies and cope with supply chain disruptions.
Sixty percent of pharmacies surveyed said they were dealing with supply chain disruptions, and nearly 70 percent said it was difficult to fill staff vacancies.
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The FDA works with manufacturers to address drug shortages, but production problems and quality issues contribute to the shortages, and the suspension of production can lead to shortages.

To manage potential medication shortages and find alternative solutions, it is essential to work closely with healthcare providers and pharmacists, who can help identify potential shortages and provide guidance on alternative medications.

Title:

Content: Prescription drug shortages lead to higher prices

Reporter: Andryanna Sheppard
Published: Updated:
Lea este artículo en Noticias WINK

Millions of people in the United States depend on prescription drugs to manage pain, treat medical conditions, and even to help them stay alive. However, the country’s drug shortage is making it hard for some people to get the medication they need or pay for the drugs that are available.

Federal Drug Administration data shows 90 percent of prescriptions in the US are for generic drugs. According to the National Institutes of Health, most prescription drugs involved in shortages are generic options.

There are currently more than 250 medications on the nation’s prescription drug shortage list, according to the American Society of Health-System Pharmacists. The organization says 2023 marked the worst year for shortages in about a decade.

Jessica Kahn’s two sons were diagnosed with ADD.

“I would say tricky, tricky to navigate,” Kahn described.

For the past year, Kahn said getting their medication has been frustrating.

“I have my list of all the pharmacies. I’ve even driven all the way up north to Walgreens or a CVS, some random place to go pick up a kids’ prescription,” Kahn added.

According to the FDA, prescription drug shortages are often linked to manufacturing and quality problems, delays, and discontinuations. Two drugs used in chemotherapy, Adderall, lidocaine, and amoxicillin are just a couple of the prescription medications on the shortage list.

When drug supplies are low, prices tend to increase. According to the US Department of Health and Human Services, there is a 16.6 percent increase in the price of drugs involved in a shortage. And in some cases, alternative drugs were priced at least three times higher.

“You got to be very conscientious that it might not be available and that it is not an option,” Kahn advised. “No matter how many places you call, it’s not there.”

Beating the prescription drug shortage

Health experts offer these tips:

  • Check the national drug shortage list for your medication and possible alternatives.
  • Don’t wait until your prescription is almost gone to refill it.
  • Check other pharmacies for availability and if you can’t find the generic version, look for coupons or programs that offer payment help. Some patients have reported that they receive additional help to reduce some prescription costs from $100 to $10, it’s not allowed if you are already on Medicare.
  • Websites and apps like GoodRX, RX Saver and WellRX can help you find the cheapest place that has your medication and coupons for it.

Contributors to this news report include: Lindsay Dailey, Producer; Bob Walko, Editor

Copyright ©2024 Fort Myers Broadcasting. All rights reserved.

This material may not be published, broadcast, rewritten, or redistributed without prior written consent.

Patients can explore alternative medications, such as Vyvanse, if their regular medication, like Adderall, is unavailable due to shortages.

Title:

Content: Clara Pitts has always strived for perfection.

The 17-year-old Utah native has been named a 2023 National Merit Scholarship finalist. And she heads to Brigham Young University as a freshman this fall.

But despite all of her achievements, Clara has one thing weighing on her mind: What if she fails?

Clara was diagnosed with attention-deficit/hyperactivity disorder (ADHD) in 10th grade, during the summer of 2020, after months of digital schooling had started to take its toll.

"For the first time, I started struggling with getting my homework done [and] having a set schedule that I had to do myself," Clara said. "It was because of online school."

So along with her mother, Rebekah, she made the decision to try medication.

"I didn't realize just how much my ADHD was inhibiting me from acting the same way as all of my friends until I had that experience of leveling the playing field," Clara said.

By December 2020, Clara was prescribed 10 milligrams of Adderall, a formulation of amphetamine mixed salts, to be taken twice a day. Immediately, she noticed a difference.

"It seemed like the logical course of action, like something that shouldn't have been happening in my brain was being fixed," Clara said. "Naturally, my brain goes really, really fast, and I don't even notice it because it's what I've grown up with, and it's the only mind I've ever experienced. But once I started having a different experience mentally, I felt a lot calmer."

For the two years that followed, Clara was finally able to lead what she called a normal life, managing school, extracurricular activities and social life -- all with the help of Adderall.

But in October 2022, Clara's sense of calm was stripped away when the US Food and Drug Administration announced a shortage of Adderall and its generic counterparts.

"I hadn't heard anything about a shortage," she said. "I didn't really take it seriously at first until later that week -- maybe three or four days later -- when I started to hear news about the shortage, and it really started to sink in."

CNN first spoke with Clara and her mother, Rebekah, about a month after the FDA's announcement. At the time, Clara had eight Adderall pills left in her prescription bottle -- enough to last her four days.

"Initially, I was just very surprised when I tried to refill the prescription and they would not [refill it]," Rebekah says. "Very quickly, I went from surprised to afraid."

On October 24, Rebekah texted Clara the bad news. The shortage had finally affected them, and their pharmacy could not refill Clara's medication due to the shortage.

"They wouldn't put you on a waiting list," Rebekah texted her daughter. "I'm just sitting here crying because I can't get you these meds."

Rebekah says she called eight local pharmacies, and each one turned up empty.

"I felt really emotional about it in that first week or two ... like I had failed my child, even though it wasn't my fault," Rebekah said. "I felt scared for what that would mean for her as a senior."

Why is there a shortage?

The FDA announced a shortage of Adderall on October 12. The agency noted that it was in communication with all manufacturers of amphetamine mixed salts and that one of those companies, Teva, was "experiencing ongoing intermittent manufacturing delays." Although other manufacturers continued to produce the drug, the agency said, "there is not sufficient supply to continue to meet U.S. market demand through those producers."

Jim McKinney, a spokesperson for the agency, told CNN that the manufacturing delay has been resolved and that the shortage is now "demand-driven."

Data from the analytics and research company IQVIA shows that the demand for Adderall has risen nearly 27% in recent years, with prescriptions jumping from 35.5 million in 2019 to 45 million last year.

On its website, the FDA lists eight manufacturers that have reported Adderall shortages to the agency. The website lists the shortage reason for some versions of the drug, such as "demand increase" or "shortage of active ingredient," but for other versions, it just says "other" or lists no reason at all.

Each year, the Drug Enforcement Administration tracks and sets a limit on production of amphetamine, one of the key ingredients in Adderall. It says that for the past three years, manufacturers didn't expend all of the ingredients that were available for their use.

"DEA is committed to ensuring that all Americans can readily access needed medications," an agency spokesperson told CNN in a statement. "We are aware that the pharmaceutical industry is claiming that there is a quota shortage for the active ingredients in ADHD drugs. Based on DEA's information -- which is provided by drug manufacturers -- this is not true."

CNN reached out to the eight manufacturers that reported shortages to the FDA.

Teva Pharmaceuticals, Epic Pharma and Rhodes Pharmaceuticals did not respond. Alvogen, SpecGX and Sunrise Pharmaceutical declined to comment.

Sandoz said it had enough product to meet current customer orders. Lannett also said it had enough to meet current customer orders but added that it did not have enough to fulfill increased demand.

McKinney, the FDA spokesperson, said supply is increasing.

"The FDA recognizes the potential impact that reduced availability of certain products may have on health care providers and patients and is working closely with numerous manufacturers and others in the supply chain to understand, mitigate and prevent or reduce the impact of intermittent or reduced availability of certain products," he said.

McKinney clarified that although the FDA is working with manufacturers, the agency does not make drugs and "cannot require a pharmaceutical company to make a drug, make more of a drug, or change the distribution of a drug."

Dr. Yoram Unguru, a pediatric hematologist and oncologist with joint faculty appointments at the Herman & Walter Samuelson Children's Hospital at Sinai and the Johns Hopkins Berman Institute of Bioethics, studies drug shortages.

He says a lack of transparency about details -- how big the shortage is and how much drug each company is making -- is hindering solutions.

"Pharmaceutical manufacturers are not required to disclose the reason for disrupted supply. Knowing the exact reason for a given shortage is always challenging," Unguru said. "It's really difficult to be able to anticipate and let alone come up with meaningful solutions if you don't know what the problem is."

The search for alternatives

Clara ultimately went without Adderall for two and half months as she coped with the stresses of senior year. She began taking a different ADHD medication, Vyvanse, in mid-January.

Rebekah says she hopes Adderall will be an option for Clara again one day, adding that she doesn't have the emotional stamina to keep searching for the medication.

"I would like her to have medication as an option and for it to be reliable, because college will probably be the hardest journey for her with ADHD."

Clara says that life without Adderall is like trying to see the world vividly while wearing smudged glasses.

"You go around with dirty glasses. You get used to it, and you don't realize that they're dirty. But when you clean them off, having that extra bit of clarity makes a world of difference."

The-CNN-Wire

™ & © 2023 Cable News Network, Inc., a Warner Bros. Discovery Company. All rights reserved.

CNN's Raenu Charles and Janelle Chavez contributed to this report.

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Pharmacists collaborate with providers to find alternative strengths and dosage changes that can help patients during medication shortages.

Title:

Content: Nationwide Adderall shortage impacting area pharmacies in the Panhandle

Published: Oct. 19, 2022 at 5:07 PM CDT|Updated: 19 minutes ago

AMARILLO, Texas (KFDA) - The Food and Drug Administration has declared a nationwide Adderall shortage and the Panhandle is feeling the affects.

The FDA blames the shortage on manufacturing delays.

Health experts say a shortage in stimulant medications is actually not a rare occurrence.

“The amount of medication that is produced is limited and regulated by the government, so there have been other years where towards the end of the year in particular, we start to struggle with supply issues. In this case, however, while that does seem to be probably one of the contributing factors, the other issue we’re facing, at least what we’re hearing about it right now, is that the manufacturing delays have been an issue and some of that has been secondary to the labor shortages,” said Dr. Carolyn Lentsch-Parcells, pediatrician and assistant professor at Burnett School of Medicine at TCU.

Martin Tipton Pharmacy is being impacted by this shortage.

“We’re having to order from various manufacturers right now, not our normal manufactures just because we cannot get them from our normal ones,” said Mark Vogler, Martin Tipton Pharmacy.

Fortunately its patients have been able to get their needed medication, just a different brand.

Amarillo Pharmacy is also being impacted, saying the drug has been back ordered for the past two months.

The Amarillo Pharmaceutical Care Center at Texas Tech Physicians is also seeing a back order on one of the strengths of the drug.

“The drug company manufacturers short-acting and extended-release, for example. So, a pharmacist, in this situation, will work collaboratively with the patient’s provider to find an available strength and dosage to meet the patient’s needs until the original strength becomes available again,” said Amarillo Pharmaceutical Care Center at Texas Tech Physicians.

Dr. Lentsch-Parcells acknowledged this may be an uneasy time for those depending on Adderall, especially with the end of the semester and holidays approaching. She encourages you to reach out to your providers.

“There are various strategies that we will sometimes use to help our patients get the best care possible, while we are trying to ride out the shortage, so that might be changing dosage or using dosage forms that are available to replace their typical medication,” said Dr. Lentsch-Parcells

She emphasizes not to make any changes to your medications without speaking to your providers first.

Pharmacy chains, like CVS and Walgreens, both confirm they are seeing intermittent supply issues with the generic form of the drug.

Checking the national drug shortage list can help find alternatives, and refilling prescriptions early can also help avoid shortages.

Websites like GoodRX can help find the cheapest medication options, and coupons and programs can reduce prescription costs significantly.

However, without knowing the specific medications your parent is taking, it is impossible to determine if they are currently in short supply or at risk of shortage.

Title:

Content: Is a prostate issue to blame for my sexual problems after I started online dating aged 76 following divorce? Ask DR ELLIE CANNON

Q: I’m a healthy 76-year-old and I just started online dating after my divorce. However, during sex I struggle to maintain an erection. Also when I climax, I experience a pleasurable feeling but produce nothing. Should I be worried about my prostate?

Dr Ellie replies: Men often experience sexual problems later in life because of an enlarged prostate or its treatment. The prostate is a small gland at the base of the bladder around the tube that carries the urine out. It is often described as being the size of a walnut, but as men age, it can become much larger than this.

Regular exercise, quitting smoking and cutting down on alcohol have all been shown to help combat erectile dysfunction

Of course, men can also get prostate cancer. An enlarged prostate will make it more difficult to urinate, due to the proximity of the prostate to the bladder, and trigger sexual problems.

These issues are typically erectile dysfunction and difficulty ejaculating. There are treatments which can combat an enlarged prostate, but it’s important to know that these too can lead to sexual problems.

READ MORE: DR ELLIE CANNON: Are the drugs I'm taking to blame for my hip pain?

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One commonly used medication for prostate problems is called finasteride, a daily tablet which can make it easier to pee.

However, more than one in 100 men who take it will have problems getting an erection and or problems ejaculating.

Men who don’t respond to medication are often offered a transurethral resection of the prostate – known as a TURP – which involves cutting away sections of the prostate.

It is thought that as many as three-quarters of men who receive a TURP will have difficulty ejaculating due to damage to the nerves and muscles in the prostate region.

Likewise, surgery to remove the prostate often leads to dry orgasms – where nothing comes out – as the gland is involved in the production of semen.

There are things you can do yourself to reduce the severity of your symptoms.

Regular exercise, quitting smoking and cutting down on alcohol have all been shown to help combat erectile dysfunction.

If the problem continues – or gets worse – then you should talk to your GP about treatment.

Q: I’m a woman in my late 70s. In 2018 I was prescribed alendronic acid after I had a fall and fractured my wrist. I have heard that you should take a break from this medication after five years but my GP says I should stay on it. I also requested another bone density scan but she said I didn’t need one. Is this correct?

Dr Ellie replies: Alendronic acid is the medication we most commonly use for the bone-thinning condition osteoporosis, and it is usually safe to take long-term.

It is taken as a weekly tablet or drink and reduces the risk of further breaks. Our bones are constantly being broken down and rebuilt by specially adapted cells within them. Osteoporosis occurs when there is too much bone breakdown happening which causes them to weaken. Alendronic acid slows down this process. Usually after five years on the treatment you would have a review of your medication to decide if you still require it. This would often involve a bone density scan, also known as a Dexa scan. A patient may stay on the medication for another five years or take a ‘treatment holiday’ and come off it for a few years.

Alendronic acid does have some common side-effects including constipation, dizziness and headaches

Alendronic acid does have some common side-effects including constipation, dizziness and headaches.

If the treatment is causing too many problems, or is failing to keep the osteoporosis under control, patients might be offered a new drug. However, it is hard to make this decision without a further Dexa scan.

The Royal Osteoporosis Society offers excellent support – you can speak with one of their specialist nurses on 0808 800 0035. After this, it would be worth requesting a conversation with the GP to establish why your medication is being continued.

Q: My GP advised I take statins, but ten days after I began the pills I developed serious pins and needles in my feet and hands. I immediately stopped taking the drug, but two months later, the pins and needles have turned into a painful stabbing sensation all over my body. My feet feel like they are burning.

Despite this, my GP refuses to see me for an appointment because he says it is a matter for a pharmacist. What should I do?

Dr Ellie replies: This is not the standard of care someone should be receiving from an NHS GP. Anyone with new symptoms or potential medication side-effects should be offered an appointment.

It might be worth looking into registering at a new practice, so you can get easier access to a doctor. Pins and needles are an uncommon side-effect of statins. The fact the sensation has continued after you stopped taking the pills could suggest it is unrelated. A feeling of electric shocks or burning, particularly in the feet, can be a condition called peripheral neuropathy where the nerves are not working properly. Peripheral neuropathy is often triggered by a vitamin B12 deficiency, and can be reversed. This is why it is crucial that you see a doctor.

If it is the statins, a GP can recommend other ways of treating cholesterol such as diet and lifestyle changes, or other medicines.

DRUG SHORTAGES PUT PATIENTS AT RISK

Medicine shortages are worse than ever, and are now affecting people’s health, according to a new report.

Supply problems have doubled since 2020, the Nuffield Trust think-tank found. GPs and pharmacists deal with this daily.

I do not recall shortages like this even being an issue

ten years ago.

Medicines for epilepsy are often in short supply. Without these, seizures are more likely and can be catastrophic. And I know parents who drive to many pharmacies to find ADHD drugs for their children.

If you have a practice pharmacist at your GP surgery, try to ask them if there are shortages of your prescription drugs, and whether alternatives can be had.

Doctors tend not to know what is and isn’t available.

Are you struggling to get hold of vital medication? Write and let me know.

Advertisement

Back pain sufferers are being fobbed off

Latest figures suggest a staggering 2.8 million Britons are ‘economically inactive’ due to ill health.

That’s double the number of ten years ago — and includes a rise of almost three-quarters of a million since the pandemic. This is probably because getting treatment for even serious problems is so difficult now.

Mental illness and respiratory diseases top the list of reasons for going long-term sick. The other most common is ‘musculoskeletal problems’, often back trouble. But back pain can be resolved quickly with advice, exercise and a physiotherapy assessment.

It frustrates me that, even if I refer my patients for the latter, it’s just not available — they’re fobbed off with phone appointments and leaflets. Have you struggled to get help with your back pain? Write and let me know.

Do you have a question for Dr Ellie Cannon? Email DrEllie@mailonsunday.co.uk

Dr Cannon cannot enter into personal correspondence and her replies should be taken in a general context.

Title:

Content: PORTLAND, Ore. (KOIN) — Concern is mounting after shortages of Adderall, a prescription medication used by both children and adults with ADHD, have gotten increasingly sparse since the quantities dropped several months ago.

The FDA says the shortage will resolve – but not until sometime in April.

Demand has skyrocketed, and while there are several alternative prescription medications, many of them are also in short supply.

Drug manufacturers say they can’t just make more of the medication because the FDA and the Drug Enforcement Administration limit the active ingredients, amphetamines, which can be abused and cause addiction. Even patients are limited in how much they can get at a time.

OHSU Psychiatrist Dr. James Hancey, who prescribes the medication, said finding the medicine is challenging because patients have to contact their doctor’s office to receive a prescription.

“It’s not one you can just walk around with to shop around for who might have the medication,” Hancey said.

There are some over-the-counter medications that some doctors are recommending as a way to get by, but Dr. Hansey said they are often not strong enough.

The shortage has been especially tough on kids who are prescribed ADHD medication to help them concentrate in school. Parents want to help their children, but are really frustrated.

There’s also concern that teenagers and adults could instead seek what could be deadly counterfeit drugs.

Title:

Content: 2 major drugs are in short supply, FDA says. Both are widely prescribed to children.

NEW!

Drug shortages continue in the U.S., even as the COVID-19 pandemic nears the end of its third year.

Two drugs commonly prescribed to children — Adderall and liquid amoxicillin — recently joined the list, the Food and Drug Administration says.

The FDA announced last month that it was talking to manufacturers about a shortage of Adderall, the combination drug of amphetamine mixed salts used to treat attention deficit hyperactivity disorder.

Parents are also discovering liquid amoxicillin — an important antibiotic used to treat bacterial infections — is in short supply, according to the FDA. It added the oral solution of the antibiotic to its list of drug shortages on Oct. 28.

Both drugs are widely used by children as well as adults. The amoxicillin shortage comes at a vulnerable time, as we enter cold and flu season and U.S. hospitals continue to fill with respiratory infections. Amoxicillin is often used to treat ear infections and bronchitis.

The reason for the shortages? The FDA didn’t immediately respond to a request for comment Thursday. However, the agency cited a few factors on its website, including quality and manufacturing issues.

“There have been other reasons such as production delays at the manufacturer and delays companies have experienced receiving raw materials and components from suppliers,” the agency says. “Discontinuations are another factor contributing to shortages.

“FDA can’t require a firm to keep making a drug it wants to discontinue. Sometimes these older drugs are discontinued by companies in favor of newer, more profitable drugs.”

For a list of all drugs currently in short supply, visit FDA.gov.

Our journalism needs your support. Please subscribe today to NJ.com.

Spencer Kent may be reached at skent@njadvancemedia.com.

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It is crucial to consult with your parent's healthcare provider and pharmacist to discuss potential shortages and alternative solutions, as they can provide personalized guidance and support.

Additionally, staying informed about medication shortages through reputable sources, such as the FDA website, can help you stay up-to-date on the latest information and make informed decisions about your parent's care.

By working together with healthcare providers and staying informed, you can help ensure that your parent receives the necessary medications and care to manage their chronic conditions effectively.

The FDA data shows that 90 percent of prescriptions are for generic drugs, and most prescription drugs in shortages are generic options.

Prescription drug shortages are linked to manufacturing and quality problems, as well as delays and discontinuations.

The FDA announced a shortage of Adderall due to manufacturing delays, and Teva experienced ongoing intermittent manufacturing delays.

Demand for Adderall rose nearly 27% in recent years, and eight manufacturers reported Adderall shortages to the FDA.

Supply chain disruptions can cause medication shortages, and lack of transparency hinders solutions to medication shortages.

The FDA works with manufacturers to understand and mitigate shortages, and manufacturing delays and demand increases can cause shortages.

To develop a plan for managing potential medication shortages and finding alternative solutions, it is essential to stay informed about the current state of medication shortages and work closely with healthcare providers and pharmacists.

By doing so, you can help ensure that your parent receives the necessary medications and care to manage their chronic conditions effectively, even in the face of medication shortages.


The global medication shortage is a concern, with 95% of raw materials being imported, affecting countries like Egypt.

The US reported 111 drug shortages in 2021, according to the FDA, and recorded 323 active drug shortages in 2021, a record high.

Twenty-eight countries, including the US and Canada, reported a shortage of penicillin-type drugs like amoxicillin.

France reported 2,160 drug shortages in 2021, rising to 3,761 in 2022 and 4,925 in 2023.

In 2024, 44% of people in France and 78% of oncology professionals reported facing drug shortages.

The World Medical Association proposed an EU-level drug reserve to address the medicine shortage caused by economic incentives.

In the US, 309 drugs were in shortage, with 99% of hospital pharmacists reporting shortages.

The FDA allowed the import of over a dozen cancer drugs, including cisplatin and carboplatin, to address a shortage.

EU manufacturing relied on imports from China and India, contributing to the shortage, and rising demand and supply chain disruption worsened drug shortages.

Shortages were caused by manufacturing, quality, and supply chain issues, and lack of transparency from pharmaceutical companies hindered the response to drug shortages and prices.

Over half of treatment shortages lasted more than two years, impacting at least 500,000 patients.

There is a shortage of 32 chemotherapy drugs for cancer, and hospitals lacked emergency medicines and ADHD treatments.

Healthcare systems have implemented strategies to mitigate medication shortages, including using alternative drugs and optimizing supply information.

Medication shortages persist, with 99% of hospital pharmacists reporting shortages and 1 in 3 health systems delaying, canceling, or rationing care as a result.

Medication shortages lead to a 16.6 percent price increase in healthcare systems, and alternative drugs can be at least three times more expensive.

The EU established a Critical Medicines Alliance in 2024 to address medicine shortages.

The global medication shortage is a concern, with 95% of raw materials being imported, affecting countries like Egypt.

Title:

Content: Chairman of Wafd Party
Dr. Abdul Sindh Yamama
Chairman of the Board of Directors
Dr. Ayman is an accountant.
Editor-in-Chief
I'm sorry.
My grandfather, Zainuddin.
Chairman of Wafd Party
Dr. Abdul Sindh Yamama
Chairman of the Board of Directors
Dr. Ayman is an accountant.
Editor-in-Chief
I'm sorry.
My grandfather, Zainuddin.
Smuggling burns drug stability
Libya and Sudan are the main destinations.
And the profits are huge.
Deficiencies include stents, heart medications, diabetes, pressure, and tumors.
It is an undeniable fact that the Egyptian pharmaceutical market is experiencing a crisis of shortage of some vital items on which citizens depend mainly, and at all levels, which exacerbated the suffering of patients in public hospitals affiliated to the government, which receive subsidized medicines at low prices, so that the so-called alternative class becomes a citizen ’ s refuge, to get the necessary dose of medicine, to alleviate his health suffering or save his life.
At a time when it is assumed that more than 90% of medicines are manufactured in Egypt, citizens' complaints about the lack of many medicines and medical supplies in the markets and hospitals are escalating to the extent that deputies submitted a number of requests for briefing through the deputies, stressing that the crisis lies in the raw material itself and imported in dollars.
And the pressure.
Thyroid and sugar.
The main reasons lie in the importation of 95% of raw materials in addition to the presence of “smuggling brokers ” whose mission is to smuggle Egyptian medicine to neighboring conflict countries, especially Libya and Sudan, in order to sell it abroad at exorbitant prices, and to reap huge profits, according to some pharmacists and specialists. In addition to Sudan ’ s import of Egyptian medicine in hard currency, especially with the licenses of Egyptian medicine compared to others and the stopping of factories in neighboring countries because of their conflicts.
According to Ali Abdullah, head of the Egyptian Society for Pharmaceutical Studies (an NGO), the lack of medicines and their disappearance from the local market is a real crisis in case of smuggling, such as insulin, tumors, anesthesia, surgical supplies, serums and vaccines.
The shortage of hard currency in Egypt is also one of the reasons for the disappearance of medicines.
Mahfouz Ramzi, head of the Pharmaceutical Manufacturing Committee at the Cairo Pharmacists Syndicate, pointed out that there are organized gangs that smuggle medicine to countries of conflicts and wars, explaining that “most operations are conducted through land border roads, and the Egyptian Drug Authority is responsible for inspecting companies, factories and any pharmaceutical institution, to ensure that medicines produced in Egypt are in the normal sequence until they reach pharmacies. ”“ Some smuggling professionals deal with drug stores, where they buy large quantities of medicines, take advantage of discounts on them, and then smuggle them abroad to take advantage of the price difference. ”
The Executive Director of the Egyptian Center for the Right to Medicine, Mahmoud Fouad, confirmed that "the drug stores have turned into an illegal business and a back gate for drug smuggling and expired drug trade, as most of them are not licensed and sold without invoices, and are not subject to the umbrella of the Ministry of Health, in addition to the lack of health standards required to practice the profession of pharmacy, after some stores are run from apartments away from the eyes of the Ministry of the control bodies. 90% of its owners are not pharmacists. ”
“Are these stores registered with the Ministry of Health?
And are they subject to pharmaceutical inspection or from the Drug Control and Research Authority? ”, stressing that most of the small pharmacies in the villages “do not have the ability to buy medicine from distribution companies, which makes them resort to buying from stores after agreeing on specific facilities and periods for payment, ” pointing out that“ popular medicines in Egypt are the most smuggled abroad. ” From 250 pounds ($8 at the official exchange rate).
According to Dr. Ashraf Hatem, Chairman of the Health Committee in Parliament, it is a social responsibility, and priorities must be set, and all parties sitting together may help to solve the crisis, in light of the apparent shortage of a number of medical drugs, and his demand that the Drug Authority publish periodically and daily alternatives to the missing medicines in the absence of the original medicine. In addition, the pharmaceutical industry continues to operate and produce.
For all this and for the continuation of the crisis of drug shortage it was necessary to search and investigate the causes and solutions!
During the meeting of Gamal al-Laith, Chairman of the Chamber of Pharmaceutical Industry at the Federation of Industries, in the presence of Minister of Health Dr. Khaled Abdel Ghaffar, the Governor of the Central Bank, Hassan Abdullah, and others, he sent letters of reassurance to the Egyptian people about the existence of a solution to pump the needs of the market of foreign currency to end the shortage of medicines. Or psychologically for the patient.
He said: « The medicines that suffer from the shortage, some of them are sugar drugs and other drugs tumors and drugs of the glands and heart, drugs related to chronic diseases, which is now being secured, and we as factories work with a stock of raw materials enough for 4-6 months, and this stock reached only weeks, and therefore we are now in the stage of risk, and therefore the government began to move ».
He added that the health sector is supported by the provision of foreign exchange resources to provide all needs according to a plan to deal with such circumstances, stressing the importance of full coordination between the unified purchasing authority and the pharmaceutical industry room as well as pharmaceutical companies to face any problems related to the shortage of supplies, medicines and medical consumables.
As well as a detailed presentation on the commitments implemented and not implemented in the period from June 2023 to January 2024, with regard to the provision of (medicines, medical supplies, laboratory supplies, devices, raw materials and packing materials), and the Minister was briefed on the results of the mechanisms established with the Central Bank of Egypt to pay the obligations in foreign currency to meet the demands of the health care sector.
In the end, the official spokesman stressed that the shortage of drugs does not exceed 15% and the drugs directed to tumors are at the forefront of the shortcomings because of their close link to the currency and what faces the supply chains, otherwise all drugs and within them are compatible... The complaints are due in their entirety to the lack of knowledge of citizens with the trade names of medicines.
In addition to the above, a severe shortage of anesthetic drugs, dental pening drugs, nephrology and recovery drugs, which will cause a real disaster that threatens the conduct of surgical operations for patients, and thus increase the waiting lists in hospitals and the occurrence of complications for patients that may result in loss of their lives.
The head of the medicine division of the Federation of Chambers of Commerce, Ali Ouf, revealed that a request will be submitted to the Egyptian Drug Authority early next week to move the prices of 1,500 items in light of what he described as developments in the situation and rising costs.
He pointed out that « the need to raise the wages of workers in the pharmaceutical sector to compensate them for the cost of living and therefore must raise salaries so that they can live in the current conditions and the sector will bear the increase of salaries at the expense of cost and raise the minimum insurance ».
On the shortage of medicines, Amin al-Dabraki, one of the dealers in the pharmaceutical market, said that the main reason for the crisis is the lack of active substances imported by companies.
This is mainly due to the dollar crisis, in addition to the withdrawal of some financial companies from the Egyptian pharmaceutical market.
On the inability of the Ministry of Health to move the prices of medicines with the movement of the exchange rate, he said that the solutions are the intervention of the state by providing a fixed customs dollar for pharmaceutical companies, while moving the prices of medicines, in addition to starting factories to produce active substances inside Egypt.

The US reported 111 drug shortages in 2021, according to the FDA, and recorded 323 active drug shortages in 2021, a record high.

Title:

Content: American Pharmacists Association Announces Record Shortages of All Types of Medicines in U.S.
World News
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The American Pharmacists Association has expressed concern about the record shortage of all types of drugs in the United States, calling on politicians to take action.
A statement posted on the association ’ s website said: “In the first half of this year, 323 active drug shortages were recorded.
It is a record higher than the previous record of 320 in 2014.
“At the federal level, significant work needs to be done to eliminate the root causes of drug shortages. ”
The statement added that particular concern was raised by the lack of sterile injectable drugs, including chemotherapy drugs for cancer and emergency medicines stored in hospital treatment rooms.
Another serious problem is the ongoing lack of treatment methods for attention deficit hyperactivity disorder in the country.
Source: Novosti
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Twenty-eight countries, including the US and Canada, reported a shortage of penicillin-type drugs like amoxicillin.

Title:

Content: Experts have recorded a shortage of antibiotics in the world due to the increase in the number of infectious diseases.
On December 21, writes the Financial Times with reference to the head of the group of the World Health Organization (WHO) for the supply of medicines and ensuring access to them Lisa Hedman, reports Day.Az.
Twenty-eight of the 35 countries for which WHO collects data are deficient in penicillin-type drugs.
In the United States and Canada complained about the lack of amoxicillin.
Less is known about the situation in poor or small countries, according to Hedman.
It is noted that in addition to the difficulties experienced by pharmaceutical manufacturers in the pandemic, the current situation is complicated by high energy prices, and this leads to a decrease in profits of companies.
In addition, countries, according to Hedman, did not expect that in the first year without masks, respiratory infections would hit the population so hard.
In addition to antibiotics, pharmacists also complain about the lack of painkillers, drugs for tuberculosis and drugs for skin infections.

France reported 2,160 drug shortages in 2021, rising to 3,761 in 2022 and 4,925 in 2023.

Title:

Content: French health groups put forward proposals to limit the damage of worsening drug shortages

Medicines such as cough syrup, lozenges and ointment are seen on a table in an apartment in Berlin, Tuesday, December 20, 2022. Copyright Stephanie Pilick/dpa via AP
Copyright Stephanie Pilick/dpa via AP
By Lauren Chadwick
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Pharmaceutical companies’ lack of transparency leads to rising drug prices and less control over public resources, the group of health organisations say.

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A group of French organisations have called for more transparency from pharmaceutical companies as drug shortages increase.

In a joint report, 14 civil society organisations outlined their recommendations to solve a “situation that has only worsened” since 2018.

The French medicines regulator signalled 4,925 drug shortages in 2023, compared to 3,761 in 2022 and 2,160 in 2021.

A 2024 survey from France Assos Santé, which represents patients, found that 44 per cent of people in France said they had faced a drug shortage this year.

One of the pharmacy unions in France has even planned a strike at the end of the month over drug shortages and what they say is worsening access to care.

Each health organisation contributed an article with recommendations for dealing with the drug shortages.

The League Against Cancer urged complete transparency on drug shortages and potential substitutions for health professionals.

They also called for monitoring of medicine stocks and their location in the country to guarantee equal access.

The organisation found in a survey published in February that 78 per cent of health professionals in oncology had been faced with a drug shortage.

Drug shortages or delays have led to anxiety among cancer patients, lost time, and worsening symptoms, the organisation said.

France Assos Santé, meanwhile, wrote that an urgent response should not be to support “the industrial sector which bears serious responsibilities” for abandoning the production of less profitable drugs, relocating drug production, and keeping insufficient medicine stocks.

They would like any cost increases justified by production costs or the risk of withdrawing a drug from the market due to it being unprofitable. They called for cost evaluations to be made public.

Their concerns also range from the use of public money to bring drug production to Europe to new government plans to prevent shortages.

Some changes at the EU level criticised

Last year, the European Commission announced several measures to reform the pharmaceutical industry and address critical drug shortages.

The European Parliament went on to adopt a position on pharmaceutical reform last month, that included “incentives for innovation” and an effort to limit overuse of antibiotics.

The non-profit organisation Prescrire, which focuses on information about medicine, wrote in a chapter they contributed to the report that while some of the European Commission’s measures were welcome, others were concerning.

One of the many measures they rejected included the Commission’s proposal to reduce the number of days of scientific evaluation of drugs from 210 to 180, which they said was necessary time rather than an “administrative obstacle”.

While the NGO welcomed some measures such as government drug shortage prevention plans, it said the Commission should allow EU states to require pharmaceutical companies to have safety stocks of medicine and sanction those that do not respect them.

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French consumer organisation UFC-Que Choisir and the European Consumer Organisation (BEUC) said that they had hoped MEPs would shorten the length of time for “data protection” to allow generic medicines to be marketed more quickly.

Instead, MEPs approved shortening the period to 7.5 years, “which is almost the same duration as the current 8 years [yet] within the framework of the text adopted by Parliament, companies can gain additional months of protection under certain conditions to reach a total of 8.5 years,” UFC-Que Choisir said.

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In 2024, 44% of people in France and 78% of oncology professionals reported facing drug shortages.

The World Medical Association proposed an EU-level drug reserve to address the medicine shortage caused by economic incentives.

Title:

Content: The Chairman of the World Medical Association (WMA) Frank Ulrich Montgomery, against the background of a shortage of certain types of drugs, called for the creation of a pan-European reserve of medicines.
This opinion he expressed in an interview published on Monday to the media group Funke, reports Day.Az with reference to TASS.
Montgomery noted that the shortage of medicines has been increasing for more than 10 years.
“The reason is misplaced economic incentives for the pharmaceutical industry, ” he said.
“For consumer goods that are not subject to patent protection, margins are estimated to be low, ‘ big pharmaceuticals ’ are no longer interested in these drugs and are shifting production to low-wage countries such as China or India.
If there is a factory burned down, the main substance is lost or there are defects in quality - suddenly the medicine will disappear all over the world, "said the head of the WMA.
A reserve of drugs at EU level as a “commitment to the pharmaceutical industry controlled and managed by the state and the medical community, ” according to Montgomery, should be created immediately.
In addition, politicians should return production sites to Europe with appropriate economic conditions.
Supply chains must be legally secured by several drug manufacturers.
Last week, pediatricians from several European countries wrote a letter to their health ministers condemning the shortage of medicines.
The German Ministry of Health recently officially announced a shortage of juices with antibiotics for children - this means that import rules can be relaxed.
The World Medical Association is an international organization, which includes more than 100 national associations of doctors, including the Russian one.
It is engaged in the development of ethical standards in medical activities, mandatory for doctors of all countries.
The association was established in 1947.

In the US, 309 drugs were in shortage, with 99% of hospital pharmacists reporting shortages.

Title:

Content: As drug shortage list grows, many hospitals face tough decisions on rationing care

More than half of hospital pharmacists are reporting a critical shortage of chemotherapy drugs and nearly all are reporting overall medicine supply gaps as prescription drug shortages near an all time high, according to a new survey.

Hospital pharmacists said drug shortages have forced 1 in 3 health systems to delay, cancel or ration care or switch to alternate drugs to continue to treat patients. And 99% are reporting some drug supply shortages, an American Society of Health-System Pharmacists survey of more than 1,000 pharmacists released Thursday found.

The organization reported shortages of 309 drugs, near the all-time high of 320 shortages in 2014. The scarcity of key drugs is prompting hospitals to find or substitute drugs and change treatment plans as needed.

“In some cases, there are no alternatives to the affected drugs, which puts patients at risk," ASHP Chief Executive Officer Paul W. Abramowitz said in a statement. "This issue requires quick action from Congress to address the underlying causes of shortages and ensure patients have the medications they need.”

Cancer drug shortages

In June, the Food and Drug Administration said it will temporarily allow overseas drug manufacturers to import some chemotherapy drugs.

The FDA allowed Qilu Pharmaceutical, a drug manufacturer in China, to import the injectable chemotherapy drug cisplatin in 50-milligram vials. Toronto pharmaceutical company Apotex Corp. will distribute the medication in the United States.

More than a dozen cancer drugs have been in shortage in recent months, including cisplatin and carboplatin, used to treat lung, breast, prostate and gynecologic cancers. The National Cancer Institute said cisplatin and similar drugs are prescribed for 10% to 20% of all cancer patients.

In June, the National Comprehensive Cancer Network released a survey of 27 academic cancer centers that found 93% reported shortages of carboplatin and 70% faced shortages of cisplatin.

When cancer hospitals face such shortages, they attempt to make sure there's enough medication for patients to finish the course of treatment, said Mike Ganio, ASHP's senior director of pharmacy practice and quality.

Cancer hospitals facing such shortages might change medications for new patients starting on chemotherapy, said Ganio, a former pharmacy manager at an academic cancer center.

"You try to keep that patient on the same regimen as much as you can, unless they're failing it for some reason, and then you would switch," Ganio said.

Steroids, hormonal drugs also in short supply

More than 1 in 5 hospital pharmacists also reported shortages for steroids, hormonal drugs and oral liquids such as lidocaine, ibuprofen and amoxicillin.

A smaller number of pharmacists said heart medications, emergency prefilled syringes and drugs used for intensive care unit patients were in short supply. Others reported shortages of attention deficit hyperactivity disorder medicines, antimicrobial drugs and injectable opioids.

In all, about two-thirds of pharmacists said the shortages were "moderately impactful," which means they are managing shortages but patients are affected.

Pharmacists are managing the shortages by offering therapeutic alternatives, buying different vial sizes or concentrations and rationing medicines.

This article originally appeared on USA TODAY: Survey: Drug shortages are widespread, hospitals ration care

The FDA allowed the import of over a dozen cancer drugs, including cisplatin and carboplatin, to address a shortage.

EU manufacturing relied on imports from China and India, contributing to the shortage, and rising demand and supply chain disruption worsened drug shortages.

Title:

Content: Brussels is planning for EU countries to share vital medicines and take emergency measures to avoid a repeat of shortages that hit the bloc a year ago.

The European Commission is proposing a “voluntary solidarity mechanism” requested by France and Germany and an early warning system flagging when drugs become scarce, according to draft proposals seen by the Financial Times. If insufficient donors come forward, EU capitals will be allowed to tap into an EU-funded stockpile set up during the Covid-19 pandemic and take other emergency measures.

In December and January western countries suffered a shortage of antibiotics including penicillin and amoxicillin, and painkillers such as paracetamol, especially in medicines used by children.

Among the emergency measures floated to prevent a repeat of that crisis, the commission could allow the extension of a drug’s shelf life, fast track approvals of alternative suppliers and support production increases.

Brussels will also encourage joint procurement of drugs from 2024 and medicine swaps with countries in the southern hemisphere, where peak winter demand happens at a different time.

The commission will draw up guidance for national stockpiles in 2024 and establish a Critical Medicines Alliance bringing governments, industry and civil society together. The commission declined to comment.

Three-quarters of countries reported a worsening of drug shortages in 2022, according to an industry survey. EU manufacturing is heavily reliant on imported active pharmaceutical ingredients from China and India.

Rising demand and disruption to supply chains have been compounded by inflation hitting the production of generic drugs, which typically sell at much lower prices than branded versions.

France has been actively encouraging the reshoring of basic medicine supply, with a giant paracetamol factory set to open in the country next year.

The EU is discussing whether to provide more funding for domestic production.

The commission’s proposal is scheduled to be approved on October 25 and could still change. Initially non-binding, it could lead to a Critical Medicines Act, with Brussels drawing up a list of vital medicines by year-end.

The commission also urges member states and the European parliament to approve its overhaul of pharmaceutical legislation, put forward in April. It includes plans to take control of drug production in the event of a public health emergency, a requirement for stockholders to inform Brussels of supply levels and for manufacturers to give early warnings of shortages.

An analysis by the European Medicines Agency and the commission found that unless there is unexpected demand the EU should avoid an antibiotics shortage this year.

“The information available today suggests that — if demand in the coming winter season does not differ significantly from the demand of recent years — the supply to the EU of key antibiotics seems to generally match demand,” the analysis said.

“However, this depends strongly on the compliance of industry with their legal obligations to ensure supply and their ability to adapt.”

Copyright The Financial Times Limited 2023. All rights reserved.
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Shortages were caused by manufacturing, quality, and supply chain issues, and lack of transparency from pharmaceutical companies hindered the response to drug shortages and prices.

Title:

Content: The lack of medicine continues to burn!
The Ministry of Health and Welfare has proposed a short, medium and long-term strategy to deal with the current 5 coping mechanisms.
Journalist Yen Zhenzhen / Taipei Report
According to the Ministry of Health and Welfare, the shortage of drugs is not a single factor, but includes supply problems, manufacturing problems, clinical demand factors, uneven distribution of drugs, drug use habits and drug prices. In addition to dealing with the relatively high clinical demand items, it is properly allocated to all levels of medical institutions and pharmacies to fully meet the needs of clinical end-use drugs.
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In the face of the shortage of drugs, Wang said, the existing health insurance uses five major coping mechanisms, including 1, a single processing window, a dedicated person to help deal with the problem of drug purchase, and contact the Food and Drug Administration to put relevant information on the website of the NHI. (4) Drug price adjustment mechanism that does not meet the cost can be re-checked according to the way of raising the price of special drugs; (5) Alternative drugs can still declare the cost, if they are not irreplaceable, they can be replaced at the same price or lower than the original prescription drug price.
In addition, Wang pointed out that in the face of the international epidemic, the Russian-Ukrainian war, and labor shortage, drug shortage is a problem facing all countries. In order to strengthen the stable supply mechanism of drugs in China, the Ministry of Health and Welfare continues to actively respond to the short-term strategy to solve the problem of drug shortage. The Food and Drug Administration (FDA) and the pharmaceutical industry have made every effort to actively arrange production lines, strive for early import, increase production / import quantity, and properly distribute to all levels of medical institutions and pharmacies to fully meet the demand for clinical end use drugs.
In addition, to properly handle the issue of drug price adjustment, the Central Health Insurance Administration of the Ministry of Health and Welfare intends to implement the "Universal Health Insurance Cost Distribution Target System (DET)" in April this year, which will adjust the number of drug prices and adjust the quota in a suitable manner, taking into account factors such as the epidemic, the Russian-Ukrainian war and inflation.
In terms of medium-term strategy, Wang said that he will establish a permanent drug shortage treatment center and optimize drug supply information transmission.
In order to speed up the handling of drug shortage incidents, we will adopt dedicated personnel and cross-departmental cooperation to develop drug shortage prevention policies to prevent drug shortage in advance, strengthen cross-departmental data integration and proactive monitoring to detect drug shortage incidents at an early stage, and intervene early through cross-departmental cooperation to stabilize drug supply.
At the same time, the Food and Drug Administration (FDA) continues to disseminate drug supply and alternative drug information through various channels. In addition to posting on the “Drug Supply Information Platform ”, the FDA will notify medical institutions and pharmacies through VPN, and weekly letters to relevant medical associations and public associations to inform members. Management system.
In the long-term strategy section, it includes reviewing the current health insurance drug pricing policy and encouraging the production of domestically manufactured generic drugs.
Wang Bi-sheng pointed out that in the review of the current health insurance drug price policy, including the development of the price protection of indicative drugs, drug price review for the lack of drugs; start the review of drug expenditure target (DET), plan the establishment of a risk control mechanism, plan the national unified procurement trial plan; comprehensively review the health insurance drug price policy, give an appropriate price protection mechanism for necessary drugs, and also target the patent period. To encourage the production of domestic manufacturers to ensure that when there is a shortage of original pharmaceutical products, there are domestic famous drugs to respond.
Wang also stressed that the Food and Drug Administration has set up a "Drug Supply Information Platform" (https: / / dsms.fda.gov.tw /), reporting hotline (02) 27878249. If medical institutions and pharmacies have any shortage of drugs, they can go to the platform for enquiry or notification, and the department will deal with it immediately.
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Over half of treatment shortages lasted more than two years, impacting at least 500,000 patients.

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Content: General Supervision
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An Unexpected Catastrophe in the World ’ s Largest Country: The Complete Story of U.S. Drug Shortages
The deficit is at a record level.
According to data from the American Society of Health System Pharmacists and the University of Utah Drug Information Service, organizations began tracking drug shortages for the first time in 2001. Steady since 2021 – now reaching a record high of 323 drugs in the first three months of 2024.
Paul Abramowitz, CEO of the American Society of Health System Pharmacists, wrote in a blog post on Thursday: “It ’ s been a long time to end drug shortages, ” and wrote:“ All drug classes are vulnerable to shortages, some of the most worrisome shortages include sterile injectable generic drugs, including cancer chemotherapy drugs and emergency drugs stored in hospital vans and procedural areas. It is dangerous for doctors and patients. ”
In addition to the 32 chemotherapy drugs that are deficient, the five categories of drugs with the greatest deficiency include central nervous system stimulants, antimicrobials, hormonal agents, and intravenous fluids. [1] The Drug Deficiency Database maintained by the American Society of Health System Pharmacists and the University of Utah is based on voluntary reports from practitioners, patients, and others that have been confirmed by manufacturers. The U.S. drug is in short supply, because it captures broader effects on service providers and patients.
The crisis has lasted a year and a half.
More than half of the treatment shortages have lasted for more than two years, according to an analysis by health consultancy IQVIA, and the average shortage affects at least half a million patients, many of them elderly, according to the US Office of Health and Human Services under the Assistant Secretary for Planning and Evaluation, which shared its analysis with Congress in May.
Growing demand can play a role in drug shortages, as with the recent shortage of weight-loss drugs, but often manufacturing and quality problems, such as supply chain gaps and downtime, are the root cause. And varied.
But the American Society of Health System Pharmacists has “serious concerns ” about parts of this proposal, especially financial sanctions imposed on hospitals that lack the resources to comply with the recommendations, Abramowitz wrote:“ We all know that managing shortages is not enough and is not a sustainable solution to the worsening crisis, and there is still a lot of work to be done at the federal level to fix the root causes of drug shortages. ”
Why Shortage Occurs
Shortages can be caused by high demand, as with the recent shortage of weight-loss drugs, but this is not usually the main problem.
The FDA also blames manufacturing and quality problems, supply chain gaps, and downtime, and Dr. Emily Tucker, a drug shortage expert and an assistant professor of industrial engineering at Clemson University, says that when there is an indication of shortages, large health systems often also proactively place large orders, adding to the system ’ s stress.
“I don ’ t blame anyone.
“When I talk to all the stakeholders – whether it ’ s wholesalers, manufacturers, or the government – everyone wants this problem to end, ” she said.
Lack of transparency
Dr. Julie Grallo, chief medical officer and executive vice president of the American Society of Clinical Oncology, told the House Committee earlier that the shortage puts providers in a terrible position: “The drug shortage crisis is forcing providers to make impossible choices, and it is also hindering the development of new drugs. Health drugs are purchased only on a price basis, and manufacturers do not have to disclose the source of their acquisition of the ingredients.
The shortage of this generic chemical drug came due to the closure of one factory in India that manufactures the active ingredient after a surprise FDA inspection found “significant quality issues, ” says Jarallo:“ We didn ’ t know, and there was no transparency regarding the company ’ s supply of the majority of active pharmaceutical ingredients to all manufacturers across the board.
Knowing this in advance, we could have responded much faster, ” Dr. Steven Schundlemeyer, director of the PRIME Institute of the University of Minnesota School of Pharmacy, which focuses on economic and management issues, told the committee that as with defense contractors in the United States, New Zealand requires manufacturers to disclose their suppliers, and that information is required.
Easily accessible in the database.
Related Topics

There is a shortage of 32 chemotherapy drugs for cancer, and hospitals lacked emergency medicines and ADHD treatments.

Healthcare systems have implemented strategies to mitigate medication shortages, including using alternative drugs and optimizing supply information.

Medication shortages persist, with 99% of hospital pharmacists reporting shortages and 1 in 3 health systems delaying, canceling, or rationing care as a result.

Medication shortages lead to a 16.6 percent price increase in healthcare systems, and alternative drugs can be at least three times more expensive.

Title:

Content: Prescription drug shortages lead to higher prices

Reporter: Andryanna Sheppard
Published: Updated:
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Millions of people in the United States depend on prescription drugs to manage pain, treat medical conditions, and even to help them stay alive. However, the country’s drug shortage is making it hard for some people to get the medication they need or pay for the drugs that are available.

Federal Drug Administration data shows 90 percent of prescriptions in the US are for generic drugs. According to the National Institutes of Health, most prescription drugs involved in shortages are generic options.

There are currently more than 250 medications on the nation’s prescription drug shortage list, according to the American Society of Health-System Pharmacists. The organization says 2023 marked the worst year for shortages in about a decade.

Jessica Kahn’s two sons were diagnosed with ADD.

“I would say tricky, tricky to navigate,” Kahn described.

For the past year, Kahn said getting their medication has been frustrating.

“I have my list of all the pharmacies. I’ve even driven all the way up north to Walgreens or a CVS, some random place to go pick up a kids’ prescription,” Kahn added.

According to the FDA, prescription drug shortages are often linked to manufacturing and quality problems, delays, and discontinuations. Two drugs used in chemotherapy, Adderall, lidocaine, and amoxicillin are just a couple of the prescription medications on the shortage list.

When drug supplies are low, prices tend to increase. According to the US Department of Health and Human Services, there is a 16.6 percent increase in the price of drugs involved in a shortage. And in some cases, alternative drugs were priced at least three times higher.

“You got to be very conscientious that it might not be available and that it is not an option,” Kahn advised. “No matter how many places you call, it’s not there.”

Beating the prescription drug shortage

Health experts offer these tips:

  • Check the national drug shortage list for your medication and possible alternatives.
  • Don’t wait until your prescription is almost gone to refill it.
  • Check other pharmacies for availability and if you can’t find the generic version, look for coupons or programs that offer payment help. Some patients have reported that they receive additional help to reduce some prescription costs from $100 to $10, it’s not allowed if you are already on Medicare.
  • Websites and apps like GoodRX, RX Saver and WellRX can help you find the cheapest place that has your medication and coupons for it.

Contributors to this news report include: Lindsay Dailey, Producer; Bob Walko, Editor

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The EU established a Critical Medicines Alliance in 2024 to address medicine shortages.