Biohacking is a practice that involves using various methods and techniques to optimize one's health and well-being, and prolong one's life, with a focus on self-optimization.

It encompasses a range of approaches, including nutrition, physical activity, supplement intake, and mental health practices, with the goal of improving overall health and quality of life.

Some popular biohacking methods include intermittent fasting, keto diets, and cold-water therapy, which have been shown to have various health benefits, such as improved mental clarity and reduced inflammation.

However, it is essential to approach biohacking with caution and carefully evaluate the potential risks and benefits of different methods and techniques, as some may have adverse effects or interact with medications.

For example, combining multiple supplements or medications can increase the risk of adverse reactions and interactions, and some supplements, such as vitamin C and aluminum, can interact with each other and increase the risk of side effects.

Additionally, some biohacking enthusiasts are experimenting with implantable chips and sensors, which can pose health risks and raise concerns about surveillance and privacy.

Neuralink and other companies are developing implantable brain-computer interfaces (BCIs) that can sense and stimulate brain electricity to control devices, with potential benefits for people with paralysis and disabilities.

However, BCIs also raise concerns about privacy, equality, and advertising in brainwaves, and ethicists highlight the need for careful consideration of these issues.

Overall, biohacking is a complex and multifaceted field that requires a nuanced and informed approach, taking into account the potential benefits and risks of different methods and techniques.

It is crucial to prioritize evidence-based practices and reliable scientific data, and to consult with healthcare professionals before starting any new supplements or medications.

By adopting a balanced and informed approach to biohacking, individuals can optimize their health and well-being, and improve their overall quality of life.

Biohacking can also involve medical screenings and the use of health wearables, such as the Evie Ring, a medical-grade health wearable designed for women.

Mental health practices, such as cognitive stimulation and stress management, are also essential aspects of biohacking, as they can help counteract cognitive degeneration and improve overall mental well-being.

The use of nootropics, such as Vyvamind and NooCube, can also support mental wellbeing and improve cognitive function, but it is essential to carefully evaluate their potential benefits and risks.

Ultimately, biohacking is a personal and individualized approach to health and wellness, and what works for one person may not work for another.

By prioritizing evidence-based practices, reliable scientific data, and careful consideration of potential risks and benefits, individuals can harness the potential of biohacking to optimize their health and well-being.

The global wellness economy is expected to reach $8.5 trillion in the next three years, with the average cost for biohacking and wellness being over $5,300 per year per American.

The longevity industry is expected to be worth 600 billion yuan in 2025, with investment in biotech driving the industry forward.

Researchers are working to improve biomarkers for healthy aging, and some consider aging a treatable disease.

However, the lack of evidence from clinical trials on anti-aging supplements makes it difficult to support their use for life extension.

Some clinical trials have shown positive results for metformin, sirolimus, and resveratrol in aging indications, but more research is needed to confirm their effectiveness.

The use of supplements like metformin, resveratrol, and rapamycin for life extension is not approved by the FDA, and their effects on human longevity are unconfirmed.

Biohacking enthusiasts often use various methods, including nutrition, physical activity, supplement intake, and medical screenings, to achieve "self-optimization" and improve their health and well-being.

Metformin, resveratrol, and rapamycin are popular supplements used by biohackers for life extension, with some studies suggesting they may extend lifespan by 10-20%.

However, the use of these supplements can also have potential risks and side effects, such as headaches, drowsiness, and anxiety.

It is essential to approach biohacking with a critical and nuanced perspective, recognizing both its potential benefits and limitations, and prioritizing evidence-based practices and reliable scientific data.

By doing so, individuals can harness the potential of biohacking to optimize their health and well-being, and improve their overall quality of life.

Biohacking is a practice that involves using various methods and techniques to optimize one's health and well-being, and prolong one's life, with a focus on self-optimization.

Title:

Content: There were 802 press releases posted in the last 24 hours and 218,846 in the last 365 days.

Jean Fallacara Guest on The Melanie Avalon Biohacking Podcast

Melanie Avalon Biohacking Podcast with Jean Fallacara

The Melanie Avalon Biohacking Podcast Episode 156 with Jean Fallacara deep dive into Neuroscience Calisthenics and Cyborggainz

Way too many people want to perform, but they don't put the right parameter and setup in place”
— Jean Fallacara
BOSTON, MA, CANADA, August 11, 2022 /EINPresswire.com/ -- Cyborgmedia LLC, is pleased to announce that our CEO Jean Fallacara was invited guest on The Melanie Avalon Biohacking Podcast Episode 156 -
The episode is airing on iTunes, iHeart Radio, Spotify, and all other podcast platforms. Join best-selling author and actress Melanie Avalon as she interviews today’s leading health and wellness experts, going beyond the fads to bring you all the biohacking tips, tricks, and techniques to effortlessly upgrade your body, brain, and life.

In this episode, Melanie and Jean took a deep dive into human performance and biohacking speaking about Neuroscience Calisthenics, achieving the Flow State, Music and the Brain
Visualization and Goal Setting, Addiction and IQ, Dopamine Pathways, Quantum Science and more.

With close than 300,000 followers on Instagram @Cyborggainz, Jean shares his knowledge of neuroplasticity, science, biohacking, and cognitive functions to explain how to incorporate functional neuroscience into sports and fitness in order to redefine workouts and enhance the performance of body and brain.

“"Way too many people want to perform, but they don't put the right parameter and setup in place.
You want to start? Put some dedication into what you're doing. That's the first thing.”
“..once you set that goal, there is no plan B. Don't think about an escape plan. If You're not convinced, you're not dedicated to it”
Jean Fallacara

- About Jean Fallacara
Biohacker, Disruptor - Master of Chaos, Risk & Figuring it out- Jean is a Serial entrepreneur, Scientist, Author, Athlete and Public Speaker.
Already ranked
-Top 10 Entrepreneurs to Follow by LA WEEKLY,
-Top 10 Motivational Influencers Canada
-Top 10 Athletes Instagram Influencers In Montreal.

Author of the Book “Neuroscience Calisthenics: Hijack your Body Clock.” Jean is also Owner of Biohacker’s Update Magazine, world’s first magazine about Biohacking and Human Optimization. www.biohackersmagazine.com
He recently accepted a position as Managing Director at inTEST Corporation [NYSE: INTT], in 2021 after his group Z-Sciences was acquired.

About Melanie Avalon
Melanie holds a certification in Holistic Nutrition from the American Fitness Professionals & Associates (AFPA), and is certified as a Wine Specialist by the internationally renowned Wine And Spirits Education Trust (WSET), achieving a perfect score for Level II. Melanie studied in the literary-based “Thematic Option” honors program at the University of Southern California. While at USC, Melanie presented in the annual Thematic Option Research Conference, received the Louise Kerckhoff scholarship for her paper “Charcot's Oppressive Hysteria: Vindicated Today?,” and contributed her “Diary of A Crazy Woman” editorial series to the Delta Kappa Alpha film fraternity’s newsletter. She later Melanie published the #1 Amazon best seller, The What When Wine Diet: Paleo and Intermittent Fasting for Health and Weight Loss.

About Cyborgmedia LLC.
From Scientific & Business Consulting, to Articles Interviews Press TV Podcasts, TedX talks, Events & More.. Unlock full potential of Human, Environment, and organization.
Career development , learning, empowering natural talents and strengths where ever they are.

We Create The Future and Optimize Your Life and Business.

CyborgMedia LLC Manages, controls & operates:

-CYBORGGAINZ Pushing human performance forward, Running all sorts of experiments in order to optimize bodies, to achieve peak performance, and upgrade physical + mental performance. -

-BIOHACKERS MAGAZINE The first magazine about Biohacking and Self Optimization, Biohacker’s Update is entirely committed to sharing all the essential hacks, updates and trends from the Biohacking World with the community at large.

-NO PLAN-B PODCAST Hosted by Jean Fallacara, discussing human optimization and the future of Biohacking with the industry experts. Jean Fallacara, Serial Entrepreneur Master of Chaos, Risk & Figuring

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Melanie Avalon Biohacking Podcast with Jean Fallacara

It encompasses a range of approaches, including nutrition, physical activity, supplement intake, and mental health practices, with the goal of improving overall health and quality of life.

Title:

Content: TV legend Davinia Taylor has revealed how well she is feeling after undertaking a new lifestyle that involves biohacking.

Biohacking occurs when someone changes their nutrition and lifestyle in order to make themselves healthier. Each person who biohacks does so in a different way whether it’s cutting out alcohol, taking supplements, or engaging in anti-ageing procedures.

Davinia – who starred in Hollyoaks – has explained that her biohacking involves cold-water therapy and removing inflammatory foods from her diet.

As a result of her new lifestyle, which also includes the use of saunas and supplements, Davinia has said that she now feels healthier than she ever has before.

Speaking to Hello! Davinia said that she entered a difficult period of poor mental health after the death of her mother when she was 35.

She added: “Boredom drove me to drink and then to eat unhealthily. I don’t want to go into my 50s feeling bored, so I had to find another way to get the dopamine I crave.”

On the techniques she uses for her biohacking, Davinia reveals that one of her routine acts is taking supplements from a company she founded. Known as WillPowders which contain collagen, protein, bone broth, and MCT (a healthy form of saturated fat) they have become an essential part of her routine.

Davinia explained: “If I don’t have my morning keto creamer and collagen, I’m going to end up binging on croissants or brownies. It’s how I’m wired after my 1980s upbringing.”

This isn’t the first time Davinia has spoken about biohacking. Earlier this year she told the Evening Standard that it wasn’t a case of taking big measures to improve one’s health.

She said: “There's so much doom and gloom… There's so much doom and gloom…There are so many little hacks you can do just to make yourself feel mentally better.”

Davinia highlighted the benefits of cold-water therapy, a method she said can be cheap to access: “The water’s freezing in this country two-thirds of the time. And on the few months a year when it’s not, just go to the supermarket, buy some ice bags and empty them into the bath.”

According to the studies, how does intermittent fasting help?

Some popular biohacking methods include intermittent fasting, keto diets, and cold-water therapy, which have been shown to have various health benefits, such as improved mental clarity and reduced inflammation.

According to the studies, how does intermittent fasting help?

What are the health benefits of the practice of bathing in cold water?

However, it is essential to approach biohacking with caution and carefully evaluate the potential risks and benefits of different methods and techniques, as some may have adverse effects or interact with medications.

Title:

Content: 18 +
• Health
• Health
Health care
Naive biohacking: why is it dangerous to take vitamins “just in case ” and is it true that hacking the body is the way to nowhere (and not to eternal life)
To live longer (for herself and her family), to avoid cancer and heart disease, biohacking enthusiast (now in the past!) and lifestyle podcaster Teresa Skrobanek conducted an experiment and plunged into the world of a thousand and one supplements for longevity.
Whose infectious example was she inspired by?
What was the danger of taking her medicine for diabetes and vitamin B capsules (it is recommended for everyone to calm down!)?
After what biohacking did Teresa really feel better?
Let ’ s share her story.
Master1305
Biohacking experiment
At the end of 2022, Teresa Skrobanek, a responsible mother and grandmother, decided to try to include “longevity ” supplements in her diet.
The general goal is to live as long as possible (for yourself and your family) and avoid breast cancer and heart disease, the risk of which is higher in women over fifty (and Teresa was 57 at the time).
Anti-age drugs were prescribed by a doctor, but, apparently, the specialist was free to relate to the ratio of anamnesis and goals of taking drugs.
In April 2023, Teresa discovered that the capsules in her medicine cabinet were metformin, which is usually prescribed to patients with type II diabetes.
Although the woman did not suffer from this disease, the doctor prescribed the drug due to the fact that the results of the studies were encouraging (but not guaranteed!) - it helps to fight aging
Teresa has also tried over-the-counter drugs, such as nicotinamide mononucleotide (NMN) supplements, which supposedly, but not proven, speed up metabolism and reduce signs of growing up.
According to the experimentalist, she followed the example of the brightest biohacker – IT billionaire Brian Johnson, who takes about two dozen supplements a day, uses at least 7 skin creams and annually spends $2 million on unusual procedures to restore youth (for example, bowel photos, blood transfusions, weekly acid peels and laser therapy).
20 supplements a day and no rejuvenation
The more and longer Teresa took the drugs, the more she doubted.
Feeling worse, and Skrobanek plunged headlong into the study of dietary supplements - the results were contradictory.
For example, studies have shown that the widely advertised low-age supplements of nicotinamide riboside (a form of vitamin B3) increase the risk of brain cancer.
And the unpleasant consequences of the use of metformin (remember, Teresa took the medicine for diabetes, not being a diabetic!) were headaches, drowsiness and anxiety.
“I started to have a headache.
I felt very tired, although the pills were supposed to give me strength, ” Skrobanek told The New York Post, with whom she shared her entire story.
How do I know that taking these substances will not harm my kidneys or liver and will not cause cancer in 5-10 years? ”
beast01
Errors made by Teresa, which can not be made by biohackers novice
At TikTok, where the hashtag # BioHacking has garnered more than half a billion views, proponents of the biohacking movement boast of swallowing 70 to 150 different rejuvenating dietary supplements every day.
For example, to slow down the aging process, businessman Joe Cohen takes rapamycin, an FDA-approved drug that a 2014 study found could help increase life expectancy.
However, Cohen told The Post that he does not recommend a strict regime to his followers: mindlessly copying from and to the anti-age program of trendsetters is dangerous!
Instead, an experienced biohacker (Joe says he ’ s been studying this phenomenon for 20 years!) encourages newcomers to take blood tests first to determine the body ’ s biological needs and deficiencies, carefully examine the benefits and side effects of any supplements, and take only what seems right.
Cohen clarifies: “By understanding your physiology, you can take certain medications that will boost your energy, mood, and chances of avoiding age-related illnesses.
Preserving health is much more important than simply prolonging existence. ”
According to the businessman, his goal is to live as long and healthy a life as possible (and not necessarily up to 150 years)!
Roman Samborskyi
If not biohacking, then what (spoiler: food)
New York City Nutrition nutritionist Diana Rodriguez agrees with Cohen.
But to start your way to longevity offers still not with tablets, but with a healthy diet: “It is recommended to use food as the first method of preventing dangerous diseases.
Fruits, vegetables, low-fat proteins, nuts and legumes, in which "tons" of vitamins and minerals, can be very useful. "
Increasing nutrient intake through organic whole foods is something Teresa Scrobanek started doing in June 2023, when she gave up the supplement diet once and for all.
And she never felt better:
“If a long life meant that I got it with terrible side effects due to taking supplements, then I would prefer a shorter, but better life, which is based on proper nutrition and training, ” concluded Teresa.
The editors remind that drugs, vitamins, dietary supplements and food products have contraindications.
A specialist consultation is required.
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Comments (0)

For example, combining multiple supplements or medications can increase the risk of adverse reactions and interactions, and some supplements, such as vitamin C and aluminum, can interact with each other and increase the risk of side effects.

Title:

Content: Many people have the habit of supplementing vitamins, and for convenience, often along with other drugs, but the Ministry of Health and Welfare Food and Drug Administration said that many people do not know that vitamins and drugs will also interact, can not be mixed to eat, especially some high levels of vitamins already belong to the category of drugs, improper use will cause side effects and other adverse reactions.
The Food and Drug Administration of the Ministry of Health and Welfare has listed the following five common vitamin and drug interactions:
1.
Vitamin C and Acid Containing Aluminum:
Aluminum acid is one of the common gastric medicine ingredients, if combined with vitamin C, may lead to increased absorption of aluminum, resulting in increased side effects, people with poor kidney function, should try to avoid combined use.
2.
Vitamin K, Vitamin E and Anticoagulants:
Vitamin K, commonly found in dark green vegetables, may reduce the efficacy of the anticoagulant warfarin; conversely, vitamin E enhances the efficacy of the anticoagulant warfarin. If you are taking an anticoagulant, check with your doctor and pharmacist.
3.
Folic acid and chemotherapy drugs:
Some chemotherapy drugs interact with folic acid, and use may lead to increased drug activity, leading to serious side effects.
4.
Vitamin B6 and Parkinson ’ s Disease Medications:
Vitamin B6 inhibits levodopa, the drug dopamine precursor for Parkinson's disease, and prevents levodopa from entering the central nervous system, resulting in decreased efficacy.
The Food and Drug Administration reminds that in addition to the above five types of vitamins, there are many other vitamins that may interact with each other.
# Vitamins # Medications # Side Effects # Interactions # Food and Drug Administration

Additionally, some biohacking enthusiasts are experimenting with implantable chips and sensors, which can pose health risks and raise concerns about surveillance and privacy.

Title:

Content: Biohacking is a controversial practice, but Lepht Anonym accepts its risks. More than once he has ended up in the ER, leaving doctors perplexed by inserting chips and even boxes with connectors into his body.

Centuries ago, when a doctor wanted to try a new vaccine or a new drug that he had created … he tested it on himself. Many died while developing new medicines.

Some biohackers they see themselves as those pioneering doctors of the Middle Ages: they test on their own body biotechnologies that aspire to improve the human being, cure diseases, and evolve the human condition, to achieve the desired happiness. And some have also died trying.

The biohacking, also known by the name of DIY biology or DIYbio, has as purpose improve our human condition making nanotechnology, genetic engineering, and technological implants available to everyone. You have more information on this card:

From its origins, Humanity pursues immortality and eternal youth. Biohacking seeks to improve our human condition with cybernetic implants. We explain who biohackers are, and why chips are installed inside the body.

Biohackers implant chips, sensors, machines and other mechanisms with the aim of overcoming physical and intellectual limits.

There is an ethical branch o legal of biohacking that only experiments with implants that do not pose a health hazard, for example chips under the skin.

But another trend is committed to not setting limits, even at the cost of putting your health at risk. Its objective is to defeat all diseases, aging and even death, with the help of technology. Then we will stop being human to become transhumans.

A first step towards posthumanism, where Humanity could dispense with its own body and live eternally as data in a neurological network.

Tips and guide to buy a next-generation sports watch that fits your needs and helps you improve your sports goals.

Within these biohackers, grinders they are the most extreme version. It is the case of Lepht Anonym, a British biohacker that, as he tells us Business Insider, more than 50 chips, antennas and other devices have been implanted in the body.

Read:  You can now install macOS Monterey with new features in Shortcuts, Safari, spatial audio in FaceTime and much more

As only professionals can use anesthesia, all Lepht Anonym implants have been inserted into your body by volunteers, to live. Your goal is “improve our quality of life through technology“.

Lepth explains on his blog that inserts its own chips because “there is no other easy way to do it. I will not wait for someone with a research laboratory to endorse this search.“.

The first chip that this biohacker was implanted under the skin, it allowed pay in stores simply by touching the card reader.

It was also implanted some magnets under the fingers, which detected external sensors to feel the distance between hands and objects. This could help blind people to move without hitting obstacles.

Hackers and the computer world are increasingly present in television fictions. Surely at the moment we can think of a series that deals with these topics, but if you can only think of one or two, we have selected a few about hackers that we find interesting.

His latest experiment, last year, has been his most troublesome. A box several centimeters long, with antennas, USB storage and connectors, was inserted under the arm. All went well until he hit his arm in a taxi, and began to swell. He had to go to the emergency room:

There the doctors told me that I was fatal, that they did not understand why I had put a box in my arm“.

In the end, he gave up: “They kept insisting that I take it off. I let them do it because they discovered that a hole had opened in one corner of the device and a large amount of a viscous substance was coming out“.

After that incident, Lepht Anonym has not updated his blog again.

The biohacking it is a practice that is just beginning. But without a doubt, it will go further. There are already medical biohackers, and the goal is to incorporate this branch of technology into medicine.

Put it in the hands of experts, because people’s health is at stake.

Neuralink and other companies are developing implantable brain-computer interfaces (BCIs) that can sense and stimulate brain electricity to control devices, with potential benefits for people with paralysis and disabilities.

Title:

Content:   1. News
August 22, 2022

Why is Elon Musk so excited about brain-computer interfaces?

Brain-computer interfaces are coming. How excited and worried should we be?

By Jake Mainwaring

Brain-computer interfacing (BCI) is like something out of a sci-fi movie. The idea of hooking up a person’s brain to a computer in order to elevate the individual’s capabilities, to augment them to overcome the limitations of their flesh, is the kind of plot device used by cyberpunk game developers and writers. However, it is rapidly becoming a reality.

Tech superstars are lining up to back BCI projects. When Tesla’s Elon Musk isn’t trying to get out of buying Twitter, he envisions a world where brain implants can empower users to do everything from climbing rocks without fear to seeing radar with superhuman vision, courtesy of his own BCI startup Neuralink.

Initially the startup aspires to give quadriplegic people the power to move a pointer on a screen with their mind. By moving a pointer, paralysed people can type, control machinery and do a whole host of life-enhancing actions.

Tech investor Peter Thiel, who most recently hit the news backing the conservative dating app The Right Stuff, has invested in Neuralink competitor Blackrock Neurotech. The startup has similar grandiose goals as Neuralink. Like Musk, Thiel originally made his fortune as one of the founders behind PayPal.

“The sky’s the limit for what BCIs will be able to do in the future, but the future is a very long period of time,” Florian Solzbacher, co-founder, chairman and president of Blackrock Neurotech, tells Verdict.

Unlike Neuralink, Blackrock Neurotech has been tested in humans. The company hopes to help people with Locked-in syndrome first, which is a type of paralysis.

“[BCIs will] help people reintegrate into society, return to work, create new social connections, and get back to a life that is much more like what many of us take for granted,” Solzbacher says.

BCI businesses have no intentions of stopping there. Neuralink ultimately wants to make BCIs commercially available and Blackrock Neurotech intends to branch out into personal protective technologies.

“After those initial medical applications, I think the next step we’ll see is first responders and others who are able-bodied, but work in dangerous, high-risk situations, use the technology to improve their reflexes or become faster, and ultimately safer, similar to the way we use wearable protective technologies now, but with far more advanced capabilities.” Solzbacher tells Verdict.

However, the wildest dreams of BCI enthusiasts are still a long way off. For now, BCIs are used to help people with disabilities overcome their limitations.

The question is how do they achieve that? How does BCIs work? Why are people investing in the technology? Read on to find out.

What is brain-computer interfacing?

So what are BCIs? In short, BCIs are computers that interface with the brain. They can sense electricity, give electricity and tell other computers what to do.

More particularly, BCIs are small computers that connect to your brain. Think blood-pressure monitors, but instead of wrapping around your arm they monitor your brain.

Brains are made up of cells called neurons. Neurons give off small amounts of electricity when they send certain messages to each other. Manmade sensors can detect those signals.

BCIs enable computers to process those patterns of electricity. The computer could, for instance, notice a signal and recognise it as the pattern for how you would normally try to move your arm. It’s not then, relatively speaking, a leap to imagine that the same pattern-tracking capabilites could be used to move a robotic arm.

In fact, that’s already been done to some extent. Researchers at Brown University have used BCIs in exactly this way to empower people with tetraplegia to reach for and grasp objects in three-dimensional space using robotic arms that they controlled directly with brain activity.

This is not the same as BCIs being able to read your mind. However, engineers do not need to read your mind to create working BCIs. All we need to know is that when we move our arms, an electric pulse happens in our brains in the same approximate location. So, if we look for a pulse there and find one, then the BCI has a pretty good idea that you are trying to move your arm.

But there’s still a little bit more to BCIs than that. Some BCIs don’t just detect pulses, they spark them off. BCIs are being developed that can detect epileptic fits before they happen and even prevent them by directly stimulating the brain with electricity.

Types of BCI

BCI developers are taking varied approaches to implementing the tech. Some require invasive surgery while others don’t.

Neuralink and Blackrock devices, for instance, attach fine threads to brain cells so they can directly record voltage from individual neurons. The threads link to the surface of the brain, making invasive head surgery necessary to install the BCI.

New York-based startup Synchron has developed another innovative BCI with clearance for testing on humans. The solution gets injected into a vein and travels to the brain where it unfurrows, embeds itself and records electrical pulses from the inside. Synchron hopes anything can do it can do without tricky brain surgery, but it has its own drawbacks. Notably, users need lots of training to use Stentrode and its functionality is more limited, since it doesn’t liaise with single neurons.

Reports have suggested Musk has reached out to Synchron’s founders to invest in the company. Details about any potential deal are scarce.

BCI technologies can be even less invasive. Some companies are developing BCIs that can be worn like a hat. NextMind’s wearable lets users move objects on a screen, and Muse provides auditory feedback to help users fall asleep.

If we don’t need surgery for BCIs, then why are the PayPal founders so invested in more invasive solutions? The short answer is that they are arguably more accurate.

The long answer requires some explaining. Non-invasive BCIs rely on electroencephalogram (EEG) scanning technology. That’s quite a mouthful, but it’s not as complicated as it might seem.

Simply put, EEG sits on top of the head no invasive surgery required. However, that also means that EEG tech is unable to pinpoint the location of an electrical signal with the same accuracy as more invasive solutions.

“[We’ll] see implantable BCIs become ever smaller and less invasive to implant, which will lead to more users both inside and eventually outside the clinical space” Solzbacher tells Verdict.

BCI is part of a bigger medtech boom

BCIs are part of a bigger boom in healthcare technology. Investments in medtech have skyrocketed year-on-year for the past decade.

Venture capitalists (VCs) like Thiel injected $914m into the sector across 220 deals back in 2013, according to data from research firm GlobalData, accessed on August 10.

Investors have clearly developed an insatiable appetite for these deals ever since. The number of deals shoot through the roof over the next eight years.

In 2021, VCs injected over $38bn into the medtech sector across 1,162 deals.

There may be dark clouds on the horizon darkening the medtech industry’s outlook. Huge swats of the tech sector in general has struggled so far in 2022. The industry has suffered down rounds and seen stocks spin into freefall. Market watchers are now debating whether or not we will see the pop of another tech bubble akin to the Dotcom boom and bust of the noughties.

It is unclear what this will mean for the medtech industry’s momentum. So far in 2022, investors have backed the sector to the tune of $12bn across 540 deals.

Transhumanist interests

BCI may have captured the imaginations of venture capitalists and the PayPal Mafia, but perhaps the most smitten will be the so-called transhumanists.

Transhumanism comes in many shapes and sizes, but transhumanists are united under the goal: technology should be integrated into our bodies to help us transcend our human limitations.

By this definition we are all transhumanists of sorts. After all, who wouldn’t endorse cochlear implants to help deaf people? The same thing goes for pacemakers and BCIs for people suffering from paralysis.

However, transhumanist most-often refers to people who want to use invasive tech beyond the medical applications. Some even think it’s high-time to take control of our evolution as a species.

A fringe of punk-transhumanists, or biohackers do take evolution into their own hands. They perform dangerous surgeries without anesthetic to embed technology in their bodies.

When this goes well they gain abilities, such as sensing electrical fields through tingling in their fingertips. But when things go wrong, as they often do with DIY surgeries, they get a trip to the emergency room.

Commercial BCIs – and the possibility of programming them – could be seen as the holy grail for transhumanists, especially with the mention of reflex-enhancing technologies, bionic limbs and gripping virtual worlds. In other words, there is a metaverse angle here too for those looking.

“BCIs wouldn’t principally change what’s possible now with a VR headset and sensory gloves, but they could vastly enhance the experience and make it feel more real, faster and intuitive,” Solzbacher says.

Feasible or fantastical?

BCIs are deeply exciting, but it does have several limitations. Firstly, everyone’s brain is different, even in ways that could be seen by the naked eye. This means there is always going to be an aspect of guesswork about which brain cells we need to look at in each person.

Fortunately, we can make a pretty good guess. Clusters of brain cells in similar locations between people have similar functions. For example the main vision processing area is generally always at the back of the head.

Still, companies like Neuralink and Blackrock cannot connect to all of the hundreds of trillions of neurons in the foreseeable future. Right now they can only access neurons on the surface of the brain, leaving trillions of neurons deep in the brain untapped.

This limitation could slow down the delivery of some of the futuristic applications of BCI. Modern limitations are actively being overcome though.

Another big limitation is with the science. Psychology and neuroscience are relatively new sciences and our brains are pretty difficult beasts to understand, especially when it comes to comprehending our experiences.

Musk has speculated that one day we might get to store and replay memories using BCIs, but Blackrock’s Solzbacher is sensibly doubtful, at least for the foreseeable future.

“When it comes to the types of things in science fiction and areas that touch on consciousness and memory, however, we don’t have the technologies today, and I don’t see them on the road map in the next ten or twenty years. Perhaps 150 years, but it’s really hard to predict that,” Solzbacher says.

Verdict asked Neuralink to comment on its technological limitations, but received no response.

Ultimately, if someone promises that their sparkling new tech will replay memories in just five years time, a healthy dose of skepticism is quite warranted.

E-ethics

We might be a long way off achieving some of the truly fantastical applications of BCIs, but when we get there we should be ready.

A new age of technology brings on a new set of ethical challenges. Fortunately, ethicists are already launching research into neurotech. Moreover, most large BCI companies have their own independent ethical review boards.

Adverts might be personalised to brainwaves. Agencies might also beam ads directly into BCIs. Although modern technology is already rife with advertising, there is something new and disconcerting about adverts residing under the skin.

The more serious ethical concerns will come if futuristic BCIs can augment reality, control movement or read any thoughts with ease.

Furthermore, if only part of the populatiion adopts commercial BCIs, then concerns about equality could also arise.

“The question is, how will we as a society – whether via public policy or cultural change – mitigate any deleterious effects,” Allen Coin, a researcher into the ethics of neurotech at NC State University tells Verdict.

Fortunately, BCIs are a long way off these sorts of implementation. The most advanced ones nowadays can move a curser on a screen, or a robotic limb.

“At this point in time, I’d argue that the raw neural data that could be gleaned is less useful than, for instance, copies of the emails that you or I would send from our phones.” Solzbacher tells Verdict. However, in the far future neural data is likely to grow in value.

In the grand scheme of BCI, these might be simple advancements. But it is these advancements that will give new possibilities to perhaps the most important users of BCIs.

GlobalData is the parent company of Verdict and its sister publications.

However, BCIs also raise concerns about privacy, equality, and advertising in brainwaves, and ethicists highlight the need for careful consideration of these issues.

Overall, biohacking is a complex and multifaceted field that requires a nuanced and informed approach, taking into account the potential benefits and risks of different methods and techniques.

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Content: How the 'original' social media craze is bringing world closer to a cure for crippling disease that killed Sandra Bullock's long-time partner

  • ALS is a progressive disorder with a life expectancy of two to five years
  • Bryan Randall, Sandra Bullock's longtime partner, died of ALS last week aged 57

It was the original social media craze, inspiring millions of people to pour freezing water on their friends in the name of charity.

But the collateral of the ice bucket challenge — which died years before TikTok was even born — is still being felt to this day.

The Ice Bucket Challenge worked by giving people two choices, similar to a 'trick' or 'treat'.

Either they had big containers of ice water poured over their heads or they made a donation to an ALS charity.

The ordeal was then filmed and once the person recovers from the icy shock, they were to nominate someone else to take the challenge.

Scientists funded by the estimated $225million (£177million) raised by the challenge, believe they're closer to a cure for amyotrophic lateral sclerosis (ALS), the crippling disorder it was invented for

Bryan Randall (pictured with Sandra Bullock in 2018) died last Saturday aged 57 after a secret three-year ALS battle. Mr Randall's family issued a statement to People confirming his death, saying: 'It is with great sadness that we share that on Aug. 5, Bryan Randall passed away peacefully after a three-year battle with ALS. Bryan chose early to keep his journey with ALS private and those of us who cared for him did our best to honor his request'

Once nominated, the person had 24 hours to do the same thing and post the evidence on social media to prove they had done it.

Scientists funded by the estimated $225million (£177million) raised believe they're closer to a cure for amyotrophic lateral sclerosis (ALS), the crippling disorder it was invented for.

The disease, which can lead to paralysis and eventually death, claimed the life of Sandra Bullocks' partner this week.

Also known as motor neurone disease (MND), it is a rare condition that progressively damages parts of the nervous system.

It occurs when specialist nerve cells in the brain and spinal cord called motor neurones stop working properly — known as neurodegeneration.

WHAT IS AMYOTROPHIC LATERAL SCLEROSIS?

ALS is an acronym for amyotrophic lateral sclerosis.

It is also referred to as motor neurone disease, or Lou Gehrig's Disease after the US baseball player when he was diagnosed in 1939 at just 36 years old.

The disease is a rare condition that progressively damages parts of the nervous system.

It occurs when specialist nerve cells in the brain and spinal cord called motor neurones stop working properly - known as neurodegeneration.

Life expectancy for about half of those with the condition is three years from the start of symptoms.

However, some people may live for up to 10 years, and in rarer circumstances even longer.

The condition can affect adults of all ages, including teenagers, although this is extremely rare.

It's usually diagnosed in people over 40, but most people with the condition first develop symptoms in their 60s. It affects slightly more men than women.

There's currently no cure for motor neurone disease.

Treatment aims to make the person feel comfortable and have the best quality of life possible

It also tries to compensate for the progressive loss of bodily functions such as mobility, communication, swallowing and breathing.

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Life expectancy for about half of those with the condition is between just two and five years from the onset of symptoms.

However, some people may live for up to 10 years, and, in rarer circumstances, even longer.

Around 5,000 people in the UK and 30,000 in the US have the condition.

Videos of people from around the world accepting the challenge, and challenging their friends, took the internet by storm, earning tens of millions of views across every social media platform.

On YouTube, a 90-second clip of founder Bill Gates welding a rope-activated ice-bucket-challenge rig over a dock from 2014 has earned more than 28million views.

Meanwhile, Lindsay Lohan's challenge on The Tonight Show With Jimmy Fallon that same year has picked up over 3.3million views.

But in 2019 an independent research organization reported that donations from the Ice Bucket Challenge enabled the ALS Association to increase its annual funding for research around the world by 187 per cent.

At the time of the challenge, the ALS Association received $115million (£90.6million), while the overall estimate of all organizations around the world stood at $225million (£177million).

And in 2016 the charity revealed the donations helped contribute to Project MinE — a study of more than 15,000 people with ALS, leading scientists to identify a new gene associated with the condition.

Known scientifically as NEK1, it provided scientists with another potential target for therapy development.

A spokesperson for ALS Association told MailOnline the Ice Bucket Challenge 'dramatically accelerated the fight' against the disease.

They added: 'It led to the development of new treatments, the discovery of new ALS genes, the creation of new global research collaborations, and the expansion of care and support for people living with ALS and their loved ones.

'It also directly funded the trials and development of Relyvrio, the first new ALS treatment approved by the FDA in several years.'

'The ALS Association is currently funding 40 more treatments in the pipeline. The current size of our research commitment is over $38million (£30million).

'We have a bold plan to turn ALS from a fatal disease to a livable one until we can cure it.

'We are urgently working to expand multidisciplinary ALS care, which has been proven to help lengthen life, and to provide care and support for everyone, regardless of where they live.'

Meanwhile, Dr Nick Cole, head of research at the Motor Neurone Disease Association told MailOnline: 'Every day researchers all around the world are making steps forward in our understanding of MND.

'Since 2016, several more genes linked to MND have been found.

'New developments in finding markers of the disease within body — biomarkers — have also progressed.

'Biomarkers could help improve diagnosis and determine if a drug is having a beneficial effect in clinical trials.'

Lindsay Lohan's ice bucket challenge on The Tonight Show With Jimmy Fallon in August 2014 has picked up over 3.3million views

He added: 'One particular biomarker, known as neurofilament light chain, played a pivotal role in the approval of Tofersen in the USA.'

The Food and Drug Administration, which polices the safety of medicines in the US, granted accelerated approval to the drug Tofersen in April.

It came after researchers unveiled the results of a global phase three trial in September last year, revealing that the drug slowed the progress of the debilitating condition in some patients.

At the time, scientists said the findings, published in the New England Journal of Medicine, were 'remarkable'.

The drug, which works by turning off the faulty SOD1 gene, which can cause the incurable disease, even allowed one wheelchair-bound man to walk again.

Les Wood, of South Yorkshire, who was diagnosed with MND 10 years ago, claimed taking part in the study had drastically improved his life, allowing him to once again enjoy holidays to Spain with his wife Val.

Dr Cole told MailOnline: 'The results from the Tofersen clinical trial and open label extension will hopefully provide proof of concept that gene-targeted therapies may be helpful for other forms of MND.

'Work is ongoing right now to develop and test therapies that will target genes in the biological pathways that may result in MND in all cases, not just those relatively small percentage of people with a specific genetic change.

'The encouraging results of the Tofersen trial have given us renewed hope by demonstrating that, with the right treatment, MND can be slowed, hopefully stopped and even reversed.'

Funds from the ice bucket challenge, 'along with other generous donors', also helped fund the MND Association’s longest running project, Project AMBRoSIA, he added.

Over the span of five years, the study collected blood, urine and skin cells from 900 people with MND as well as from over 400 people without the disease.

'Project AMBRoSIA provided further evidence that neurofilament light chain could be used to screen new potential treatments to find the most promising candidates to be tested in larger trials,' he added.

The condition can affect adults of all ages, including teenagers, although this is extremely rare.

It's usually diagnosed in people over 40, but most people with the condition first develop symptoms in their 60s.

It affects slightly more men than women.

Treatment aims to make the person feel comfortable and have the best quality of life possible.

It also tries to compensate for the progressive loss of bodily functions such as mobility, communication, swallowing and breathing.

Last week the ALS Association revealed that the death of Sandra Bullock's partner Bryan Randall sparked a 500 per cent increase in donations to the charity.

The photographer died last Saturday aged 57 after a secret three-year ALS battle.

The family asked for people to donate to the ALS Association instead of sending or buying flowers.

Mr Randall's family issued a statement to People confirming his death, saying: 'It is with great sadness that we share that on Aug. 5, Bryan Randall passed away peacefully after a three-year battle with ALS.

'Bryan chose early to keep his journey with ALS private and those of us who cared for him did our best to honor his request.'

ALS can be difficult to diagnose in early stages since symptoms are similar to those in other diseases.

However, a patient might have biopsies of their muscles or nerves, as well as blood and urine tests to rule out other causes.

In April, the Food and Drug Administration (FDA) authorized the first drug, sold under the brand name Qalsody, for ALS cases with a gene mutation known as SOD1. This is present in about two percent of cases

Researchers unveiled the results of a global phase three trial in September last year, revealing that the drug slowed the progress of the debilitating condition in some patients. The drug, which works by turning off the faulty SOD1 gene, which can cause the incurable disease, even allowed one wheelchair-bound man to walk again. Les Wood, of South Yorkshire, who was diagnosed with MND 10 years ago, claimed taking part in the study had drastically improved his life, allowing him to once again enjoy holidays to Spain with his wife Val. Pictured, Mr Wood in 2017, a year after starting on the drug

Additionally, an MRI scan of the brain and spinal cord can reveal ALS changes.

In some cases, an electromyogram (EMG) may be performed. This is when a needle is inserted through the skin into the muscles to see if there is damage.

Similarly, doctors may perform a nerve conduction test, which measures the nerves' ability to send signals to muscles, and can determine if a patient has nerve damage.

Equally, studying and developing treatments for MND has proved 'extremely challenging', experts told MailOnline.

For the disease represents a fundamental neurobiological challenge to researchers.

Dr Oscar Wilkins, post-doctoral researcher at the Francis Crick Institute and UCL Institute of Neurology, said: 'It requires us to understand and help fix arguably the most complex cells in the whole human body: motor neurons.

'These cells are very challenging to grow outside of a living animal, and furthermore they interact with many other cells in the body - simulating these conditions in an experimental setting is hugely challenging.

'Whereas with cancer the aim is simply to kill rogue cells, with MND we have to do something much more difficult: keep these incredibly complex cells alive.'

The approval of Tofersen however is 'exciting', he added.

'Furthermore, there are numerous new therapies being developed which target more common forms of MND, some of which may be applicable to around 97 per cent of patients.

'All of this is made possible by funding from charities, so the money raised by schemes such as the ice bucket challenge make a real difference.'

Meanwhile, Dr Cole at the MND Association said: 'It is not only gene targeting therapies that are being worked on, the MND research community is coming at the disease from all angles.

'No stone is left unturned in the fight to understand the biology of the disease and to find treatments – research is looking at the inflammation, the gut biome, autophogy — waste management — RNA processing and even the potential of ancestral viruses causing MND.'

Last week the ALS Association revealed that the death of Sandra Bullock's partner Bryan Randall sparked a 500 per cent increase in donations to the charity. His family asked for people to donate to the ALS Association instead of sending or buying flowers

A 2021 study by researchers at the University of Sheffield for instance, found frequent strenuous exercise increases the risk of developing MND in certain people.

Research suggested a causal relationship between exercise and MND, with high intensity physical activity likely to contribute to motor neurone injury in people who have a predisposing genetic profile.

At the time scientists said the study represented a significant step towards unravelling the link between high levels of physical activity and the development of MND.

Professor Michael Swash, an emeritus  professor of neurology at Queen Mary University of London, told MailOnline: 'The first requisite for devising an effective medication is clearly to break through into understanding of causation.

'This has proven, as expected, a major neurobiological problem, but very great progress has been made and is continuing and at some point this will translate into practical benefit.

'The future depends on people — bright, educated, neuroscientists and neurologists.

'Training posts are essential in encouraging young entrants into the field of study, and all the MND/ALS associations across the world have utilised their funds to accomplish this, with striking results in new knowledge.'

He added: 'Big Pharma’s themselves play a key role in developing putative therapies, but these treatments arise from ideas developed in basic scientific research, so there is an essential interaction between the philanthropy of the voluntary organisations, other funding bodies and generous individuals, and the profit motive of big Pharma. All are important.'

Meanwhile, Professor Andrea Malaspina, clinical director of the UCL Queen Square MND Centre, added: 'We are at the most hopeful turning point for research and treatment into ALS/MND and its many sub-types.

'New potential therapies include conventional drugs and now gene-based approaches.

'However, all of this requires considerable levels of funding to move promising therapeutics into new and cost-effective clinical trials platforms and then, we hope, into the clinic for the wider patients' benefit.'

She added: 'It’s likely that at first there won’t be a single ‘wonder drug’ but probably a set of treatments given together, and again, this makes the need for funding even more urgent.'

It is crucial to prioritize evidence-based practices and reliable scientific data, and to consult with healthcare professionals before starting any new supplements or medications.

By adopting a balanced and informed approach to biohacking, individuals can optimize their health and well-being, and improve their overall quality of life.

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Content: Home » biohacking, reprogramming mind and body to live better

biohacking, reprogramming mind and body to live better

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It’s called “biohacking” and it comes from Silicon Valley. Listen: The long life diet: the longevity formula is calorie restriction …

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It’s called “biohacking” and comes from Silicon Valley.

A relatively new word that comes from the union of “biology” and “hacker” and indicates the attempt to positively influence the functioning of the organism, by hacking, ie trying to “force”, one’s genetic heritage. A strategy to live better and longer launched years ago by Californian top managers and which then spread throughout the world. How to upgrade the “operating system” of the human body? No manipulation, here we are talking about “reprogramming” and new lifestyles. “Our genetic heritage has enormous unexpressed potential that can be activated,” he explains Fabio Piccinidoctor and psychoanalyst, researcher of Food Sciences of theMarche Polytechnic University, author of the book “Biohacking Techniques: how to optimize metabolism to increase health and longevity”. “Biohacking aims to activate epigenetic modifications by awakening dormant genes to enhance the body’s resources.” While genetics studies the structure of DNA, epigenetics the way genes express themselves, i.e. how much they are turned on or off. “We’re talking about a set of strategies that aim to strengthen the body from a physical and mental point of view, first of all through nutrition, sleep quality, physical activity, cognitive stimulation”. One of the pillars of biohacking and the intermittent fasting, Piccini adds, which plans to concentrate the diet in a precise time span of the day (to be followed always under medical supervision). «But it is equally important to take care of sleep, we know very well that sleep debt accelerates aging and that 30-40 percent of people sleep too little. Just as it is essential to check thehydration. Physical training must also be intermittent, with recovery periods in place to allow the muscle layers to rebuild. And then, you have to keep learning something at any age, another pillar of biohacking: studying music or a new language, for example, to counteract cognitive degeneration”.

See also  The dashboard of Xbox Series X will have a higher resolution-

THE QUALITY OF LIFE

Sandra Milo is one of the supporters of this well-being and longevity strategy. «I’m lucky, at 90 I’m in full health and I still have a great desire to enjoy life. I don’t know if it’s a matter of genetics, nor do I think there is a “magic formula” of longevity, but I have certainly always been careful to lead a healthy life. There is nothing more beautiful than reaching old age with a smile and in full autonomy », says the actress who baptized the first Biohacking Suite in Rome. “Our mission is not so much to lengthen life but to improve its quality by lowering the rate of morbidity,” explains Dr. Claudio Urbani, specialist in regenerative medicine, neuroscience and stress therapy, head of the longevity center Umb. «Biohacking aims to modify dormant functional responses from non-use, from muscular or cardiovascular function to flexibility. It is about regaining possession of the body and the mind-body axis, starting with stress management». Diagnosing your own state of “aging” involves a series of tests. «The measurement of oxidative stress which measures the quantity of free radicals and indicates any inflammatory states, plethysmography to evaluate the functionality of the microcirculation of the legs, impedancemetry to study body composition, fat and lean mass, nutritional status and hydration level. And only after the check is a tailor-made program created for each person. Among the suggested therapies, there is also that of the cold which stimulates the metabolism and reduces inflammation ».

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Biohacking can also involve medical screenings and the use of health wearables, such as the Evie Ring, a medical-grade health wearable designed for women.

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Biohacking & Toxic Masculinity: How Women Dismantled The Boys Club

Author: Medical reviewer:
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By Jamie Schneider
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Jamie Schneider is the Beauty Editor at mindbodygreen. She has a B.A. in Organizational Studies and English from the University of Michigan, and her work has appeared in Coveteur, The Chill Times, and Wyld Skincare.
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Take a quick search for “biohacker” on TikTok (a tag with over 137 million views), and you’ll discover a slew of men discussing their muscle gains, testosterone levels, and cold plunge routines. You’ll see some women on the page, but the space is undoubtedly dominated by male energy. And think of the outspoken biohackers you may listen to on podcasts—chances are most of them are men, too.

This gendered approach to biohacking, while pervasive, is simply misguided. But now, women are asserting their authority in health optimization, and we expect their emphasis to soar in the year ahead.

Meet the experts

Molly Maloof. M.D.

Molly Maloof. M.D. provides health optimization and personalized medicine to high-achieving entrepreneurs, investors, and technology executives. Since 2012, she has worked as an advisor or consultant to more than 50 companies in the digital health, consumer health, and biotechnology industries. Her company, Adamo Bioscience, is working on sexual health optimization.

Gabrielle Lyon, D.O.

Gabrielle Lyon, D.O. is a board-certified family physician leading a disruption in modern medicine that focuses on the largest organ in the body: skeletal muscle. With a background that includes a combined research and clinical fellowship in geriatrics and nutritional sciences at Washington University and undergraduate training in nutritional sciences at the University of Illinois, she is a subject-matter expert on protein for health, performance, aging, and disease prevention.

Stacy Salvi

Stacy Salvi is the vice president of product and strategy at the medical device company Movano Health—the creator of the Evie Ring, the first medical-grade health wearable designed for women.

Mona Vand, PharmD

Mona Vand, PharmD studied pharmacy at Massachusetts College of Pharmacy and Health Sciences before developing her platform that shares holistic wellness advice.

Why biohacking isn’t just for “bros”

“Women are the original biohackers,” declares family physician, Molly Maloof, M.D. “Our hormones change throughout our lives, and this requires us to adapt accordingly.” Our biology means that women often need to constantly edit their health routines and experiment with lifestyle habits as time goes on. Isn’t that the very definition of biohacking?

Let's back up: Here at mindbodygreen, we think of “biohacking” as the practice of making lifestyle tweaks to optimize health and promote longevity. Not shortcuts—contrary to popular belief—but low-lift, everyday habits that complement and enhance an existing well-being routine. Think: optimizing your exercise regimen using tools and techniques (the “biohacks”) to enhance muscle growth. It’s essentially all about advancing health with “do it yourself” biology—a topic that can pique anyone’s interest, regardless of gender.

“[Women] have a most complex physiological lifecycle that requires us to track and manage fertility, pregnancy, breastfeeding, sexuality, perimenopause, and menopause. So we should be looking at biohacking as a path to even greater health and owning the opportunity to improve our lives,” says Maloof.

Yet many women feel intimidated to enter the biohacking scene as it exists today, turned off by the male-dominated energy in the room.

Women are the original biohackers

Molly Maloof, M.D

“Biohacking has always grabbed my attention, and I want to learn, but it sometimes makes me really stressed out, because I go into this state of perfectionism where I have to do all the things,” says doctor of pharmacy and wellness practitioner Mona Vand, PharmD. “The few biohackers that I followed were all males… it just doesn't really resonate with my energy.”

This male energy is not only frustrating but can potentially harm women’s health in the long run. After all, building muscle, prioritizing protein, and keeping an eye on various health metrics are crucial for longevity—in some cases, these proactive measures can save lives. When women don’t get involved, it can totally impact their well-being.

“Physical strength is nonnegotiable,” says functional medicine doctor Gabrielle Lyon, D.O. “I've been a physician since 2006, and I've never heard someone say, ‘I regret being physically strong.’” And the muscle-building space impacts more than just physiological changes, she says. “You optimize fertility, you make healthier babies, you help the epigenetics of your child,” Lyon adds. “You age better, your skin is better, you're less likely to fall and break a hip… There's nothing that doesn't get better the stronger you are.”

So let’s be clear: Dismantling the biohacking boy’s club is not just about helping women feel included; there are real health implications at stake here.

Why the biohacker space actually really needs a dose of feminine energy

I’d be remiss not to mention how biohacking culture can easily become synonymous with hustle culture (some experts don’t even like to use the term, as it implies you can achieve optimal health with quick fixes). But as more women enter the biohacking space, we expect it to become more intuitive and less about hitting every single benchmark. From there, we predict women will focus more on sustainable changes long-term instead of a gazillion quick hacks.

“I used to think it was a flex to do a million things at the same time and habit stack,” Vand recounts. “I now carve out time for doing things that have no efficiency to them, that are strictly for joy or rest and relaxation, versus benefiting my longevity or health. It can be a little bit obsessive when you get into this thought pattern, and I just don't resonate with it.”

This doesn’t mean biohacking will become “softer” as it embraces feminine energy. But there’s an opportunity here for women to introduce some much-needed flexibility into a space that has long felt needlessly rigid.

How the biohacker game is changing — and where it’s headed next

Thanks to a growing awareness that healthcare protocols should not be gendered, more women are now starting to pay attention to markers of performance like lean muscle, hormetic stressors, VO2 max, HRV, zone 2 training, etc. “Cold plunging, saunas, and harder, more physical activities are not just for the boys anymore,” adds Lyon—and we expect an even bigger shift to come in 2024.

“I think it’s super exciting to see biohacking become more mainstream and more women joining the conversation,” adds Maloof. She praises apps like Wild.AI, for women who aim to make lifestyle adjustments based on their menstrual cycle, and Zero, for women who want to dabble in time-restricted eating, both of which have helped to herald the shift.

Other existing health optimization companies are now inviting women into the conversation by introducing specific features informed by their unique physiology. WHOOP, for example, is currently working on upgrades to their popular health-tracking band: “We did a study recently where we learned a lot about how a woman's body changes during pregnancy and how her heart rate variability (HRV) will evolve. It'll decrease, and then about seven weeks before she gives birth, it will increase sharply,” explains Will Ahmed, WHOOP founder and CEO, on the mindbodygreen podcast

If a woman didn’t know that this was supposed to happen, she might look at this stark increase with a critical (or anxious) eye. “We've been able to take population-level data on pregnant women and now have a feature in the app, where a woman can see how her body is evolving alongside what other pregnant women are experiencing,” he adds.

Similarly, creatine supplements—from the ingredients to the packaging—are no longer marketed toward dudes looking to bulk up, and we are certainly here for it. After all, muscle mass is a predictor of longevity and healthspan, so supplements that promote it can help all of us “hack” our health in a big way.

And as Lyon notes, women have lower endogenous creatine stores compared to men (meaning, they have less available). And the amino acid has been associated with significantly increased muscle mass1 in both men and women, without increasing the risk of adverse outcomes2, like weight gain. “Most of the women in my practice will go on creatine, and they find anecdotally that it really improves both anaerobic and aerobic exercise performance,” Lyon shares.

Not to mention the supplement’s brain health perks: Taking creatine has been shown to benefit both working memory and processing speed3 as well as cognitive longevity4. “It is above and beyond simply sport performance,” adds Lyon, who has certainly seen an uptick in women curious about creatine.

As women feel intimidated (or even restricted) by biohacking spaces, some experts have taken it upon themselves to create new ones that center the feminine. For example, neuropsychophysiologist Kayla Osterhoff, MPH, offers a Women's Biohacking Mini Course, consisting of lifestyle routines and tips aligned with female physiology.

Osterhoff also recently presented at the 2023 Dragonfly Live Conference—among other female biohackers—to discuss the latest advancements in women's well-being and the “health revolution” that’s sweeping the mainstream. This conference aims to gather the “who's-who” in the health space to discuss cutting-edge strategies and innovations that optimize well-being—by having women biohackers at the forefront of the conversation, we can expect them to hit the main stage in a broader sense.

Or take the brand new Evie Ring, the first medical-grade health wearable designed for women, created by medical device company Movano Health. The technology ties hormonal information to a woman’s sleep, activity, and heart health data (among other metrics).

For instance, “If we notice a more restless night of sleep in the luteal phase, we'll point it out and also give some strategies for how somebody may attack their day, despite having not gotten as good of a night of sleep,” says Stacy Salvi, vice president of product and strategy at Movano Health. Similarly, “We know that there are cardiovascular implications when your estrogen drops, so they would want to keep a better look on the function of their heart,” she adds. “This would be something that they would be able to do from our app.”

Even the design itself was made with women in mind: The ring features an open band meant to accommodate how women’s fingers change in size throughout the day, so it can stay comfortable.

To avoid needless stress, Evie also limits the amount of goals you can set on the app. “You can only set three at a time, because we do not want to overwhelm [users] with a bunch of different things,” says Salvi. “I mean, I'm an overachiever. I probably would set every single goal and then fail at them.” And heaven knows we don’t need yet another way for busy, overwhelmed women to feel like they’re failing in a society with unsurmountable standards.

Forecasting the future

A woman walks up to the weight rack in 2024. She sees the usual suspects—bros pounding protein shakes and grunting through their bicep curls—but now she also sees a fair amount of women on the scene. They’ve got creatine supplements! Fitness trackers! Kettlebells! (And no, they aren’t pink.)

Granted, we still have a ways to go before women feel totally embraced by the biohacking space (we’d first have to close the centuries-long gender gap in science and medicine), but it’s clear that the arena is becoming way less of a boy’s club. “And the world is ready, my friend,” says Lyon. “The world is absolutely ready for this.”

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Mental health practices, such as cognitive stimulation and stress management, are also essential aspects of biohacking, as they can help counteract cognitive degeneration and improve overall mental well-being.

The use of nootropics, such as Vyvamind and NooCube, can also support mental wellbeing and improve cognitive function, but it is essential to carefully evaluate their potential benefits and risks.

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Best Over The Counter Adderall Australia Alternatives 100% Natural

Last Updated 08 December 2023, 12:11 IST

Adderall Australia, a strong prescription medicine often given for conditions like Attention Deficit Hyperactivity Disorder (ADHD), is famous for its ability to improve attention, focus, and energy levels. However, because of possible side effects and the risk of abuse, many people are looking for alternatives. This has led to more demand for over-the-counter (OTC) options that can give similar benefits without the problems linked to prescription drugs . In this article, we explore the closest non-prescription option to Adderall Australia, comparing natural stimulants, cognitive boosters, and even nootropic mixes to give you the needed knowledge for making a smart decision.

Best Over The Counter Adderall Australia Alternatives Supplements

1#. Noocube: Click Here To Buy (Official Website)

2#. Brain Pill: Click Here To Buy (Official Website)

3#. Mind Vitality: Click Here To Buy (Official Website)

Whether you are interested in finding a natural replacement for Adderall Australia for daily use, looking for over-the-counter stimulants to increase cognitive performance , or curious about the potential of natural nootropics, this detailed guide has you covered. We will look into legal alternatives to Adderall Australia that do not need a prescription, focusing on natural focus boosters and brain supplements made to improve mental skills.

Vyvamind – Best Overall (Editor’s Pick)

VyvaMind works as an independent company that only makes their main product. This focused way is often seen positively in the supplement industry, as it shows a more complete commitment to product development and careful testing.

In the case of VyvaMind, their website shows a thorough research and development process that lasted for several years. They have reached version 4.2.1 of their product, showing a way of improvement for maximum effect.

Get VyvaMind for The Most Discounted Price Online – Safe Purchase Guaranteed!

How it works: A key part in Vyvamind is caffeine anhydrous, a dried form of caffeine famous for increasing alertness and mental sharpness. Also, it adds L-Theanine, a common nootropic part with the ability to stop the bad effects of stimulants.

Vyvamind is the most similar over-the-counter option to Adderall Australia. While it may not be as strong as Adderall Australia, it successfully copies its effects and is legally available without the need for a prescription. The addition of essential B vitamins, important for nerve function and dopamine breakdown, further improves Vyvamind’s appeal. This unique combination of parts makes Vyvamind a safe, legal, and very effective alternative to Adderall Australia.

VyvaMind ingredient Advantages:

Its mix of B vitamins, especially B6 and B12, has shown the ability to improve overall brain health and protect against cognitive decline. Caffeine Anhydrous, a type of caffeine, adjusts focus and reduces feelings of tiredness. Citicoline, a strong part, greatly improves cognitive performance across many areas, increasing focus, concentration, energy levels, memory, and mood. L-Tyrosine, an amino acid, helps to improve concentration and creates a sense of calmness in high-stress situations, finally creating an improved mood. L-Theanine, another amino acid, has a calming effect on the brain, resulting in better focus, more attention, and more creativity by changing serotonin, GABA, and dopamine levels in a balanced way. VyvaMind ingredient selection is carefully chosen to work together, creating lasting focus and concentration. Price: For the most trustworthy purchase of this nootropic supplement, we suggest getting it directly from the official website, where you can choose from three different packages:

The basic package, which gives a 30-day supply, is priced at $74.99. The standard package, giving a 2-month supply,

Nooceptin is a natural product that helps you improve your brain function, made with carefully measured ingredients that have noticeable effects. It has many benefits, such as better focus, more energy, and less stress. This product is specially designed to increase blood flow to the brain, strengthen brain connections, grow new brain cells, and balance important brain chemicals such as acetylcholine. This complete approach is meant to boost mental speed, improve memory, and reduce stress and anxiety.

How it works: It is important to know that Nooceptin may not work the same for everyone, as some nootropics may interact with some medicines (such as SSRIs, blood pressure medicines, and ADHD medicines).

Also, Nooceptin says that its product has been tested in a clinic. In this Nooceptin review, our goal is to explore all aspects of Nooceptin and help you decide if it is right for you.

Nooceptin uses natural ingredients that make the brain produce more BDNF and NGF. These substances are important for protecting and growing new brain cells, which helps with thinking and memory. The increased production of BDNF and NGF, helped by Nooceptin, also protects the brain from damage caused by aging, stress, and other factors.

Advantages:

Helps control blood flow to the brain for better focus and energy Helps grow more brain cells Makes brain connections faster Lowers stress and anxiety Increases the level of the important brain chemical acetylcholine Improves memory and recall Helps you use the full potential of your brain Price: Also, ordering Nooceptin from its official website makes sure that you get the real and original product. Now, let’s look at the prices of Nooceptin:

●     One bottle of Nooceptin: $69 with free fast shipping.

●     Two bottles of Nooceptin: $138 with free fast shipping.

●     Three bottles of Nooceptin: $207 with free fast shipping.

Mind Vitality

Mind Vitality is made to increase your mental energy, so you can do things easily without getting tired. This supplement is your way to overcome laziness and succeed in your field. It’s your secret tool for increasing productivity, improving focus, and reaching peak performance.

Each Mind Vitality capsule has a mix of 19 carefully chosen ingredients, a blend of vitamins, herbal extracts, minerals, and amino acids. These ingredients, called ‘nootropics,’ boost brain function, making sure you stay ahead in your work or studies. With these scientifically proven nutrients, you’ll use your mental power to the fullest.

How it works: Mind Vitality works by improving your cognitive functions, raising brain fuel levels, and making brain cell membranes work better.

Every ingredient in Mind Vitality was carefully selected and tested to make sure this nootropic supplement works well.

This explains its amazing ability to clear fuzzy thinking, increase overall productivity, while keeping its safety and natural composition.

Also, this product is gluten-free, vegan-friendly, and non-GMO, so it fits different dietary needs.

Nooceptin is a natural product that helps you boost your brain function, made with exact ingredients that have clear effects. It has many good things, such as more focus, more energy, and less stress. This product is made to make more blood go to the brain, make brain connections stronger, grow new brain cells, and control important brain chemicals such as acetylcholine. This whole approach is meant to make mental speed faster, make memory better, and lower stress and anxiety.

How it works: It is important to know that Nooceptin may not work the same for everyone, as some nootropics may not work well with some medicines (such as SSRIs, blood pressure medicines, and ADHD medicines).

Also, Nooceptin says that its product has been tested in a clinic. In this Nooceptin review, our goal is to look at all parts of Nooceptin and help you decide if it is good for you.

Nooceptin uses natural ingredients that make the brain produce more BDNF and NGF. These substances are important for keeping and growing new brain cells, which helps with thinking and memory. The more production of BDNF and NGF, helped by Nooceptin, also protects the brain from harm caused by aging, stress, and other factors.

Advantages:

Helps manage blood flow to the brain for more focus and energy Helps grow more brain cells Makes brain connections faster Lowers stress and anxiety Increases the level of the important brain chemical acetylcholine Makes memory and recall better Helps you use the full power of your brain Price: Also, ordering Nooceptin from its official website makes sure that you get the real and original product. Now, let’s look at the prices of Nooceptin:

●     One bottle of Nooceptin: $69 with free fast shipping.

●     Two bottles of Nooceptin: $138 with free fast shipping.

●     Three bottles of Nooceptin: $207 with free fast shipping.

Mind Vitality

Mind Vitality is made to raise your mental energy, so you can do things easily without getting tired. This supplement is your way to beat laziness and do well in your field. It’s your secret tool for making productivity higher, making focus better, and reaching top performance.

Click Here to Buy Mind Vitality From The Official Website

Each Mind Vitality capsule has a mix of 19 chosen ingredients, a blend of vitamins, herbal extracts, minerals, and amino acids. These ingredients, called ‘nootropics,’ make brain function better, making sure you stay ahead in your work or studies. With these proven nutrients, you’ll use your mental power to the fullest.

How it works: Mind Vitality works by making your cognitive functions better, increasing brain fuel levels, and making brain cell membranes work better.

Every ingredient in Mind Vitality was chosen and tested to make sure this nootropic supplement works well.

This explains its great ability to clear fuzzy thinking, make productivity better, while keeping its safety and natural composition.

Also, this product is gluten-free, vegan-friendly, and non-GMO, so it fits different dietary needs.

Improved mental sharpness, making faster and more effective thinking when under pressure. Price: Mind Vitality is only available through its official website. Below, we show the pricing details for this nootropic supplement:

Single bottle of Mind Vitality - $69.99 Pack of three bottles of Mind Vitality - $139.99 Set of five bottles of Mind Vitality - $209.99 Every order of Mind Vitality comes with free and fast shipping.

Noocube

Noocube is a cognitive enhancer with the main goal of making mental performance better, making memory better, making communication better, making mental energy better, and making concentration levels better. Its main mission is to help people overcome mental challenges that might stop them from reaching their life goals. Noocube’s composition has natural ingredients, including botanical extracts, amino acids, and vitamins, known for their claimed clinical effectiveness. Some of these botanical extracts have been part of traditional medicine for many centuries.

Click Here to Order Noocube for the Best Price Available At The Official Website!

How it works: The company suggests a morning routine of two Noocube capsules for best results. The supplement’s cognitive effects usually start to show within 30 to 45 minutes after taking it.

Based on an average customer review, Noocube’s benefits may last for about eight to ten hours, making it a good choice for keeping focus throughout the day.

Noocube makes cognitive ability and memory better by giving the essential nutrients and energy that your brain needs for working well. Besides making cognitive abilities better, Noocube might help to lower the risk of conditions like Alzheimer’s and dementia. This is because of the neuroprotective properties of some ingredients in Noocube, which may help to protect brain function as you age.

Advantages:

Noocube Brain Productivity has 13 proven ingredients that effectively remove cognitive cloudiness, make the energy of brain cells better, and make mental abilities better. Choosing this option to Adderall Australia over prescription medicines offers many benefits, including:

Improved cognitive functions including better decision-making and problem-solving skills. Lowered stress levels and a better mood. Improved accuracy and concentration. Helping brain cell growth and making blood flow to the brain better. More motivation for finishing projects. Easier starting and keeping of good sleep. Price: There are three different Noocube packages available for buying through the website:

A single Noocube bottle, with 60 capsules made for one month’s use, is priced at $59.99.

●     A three-month supply of Noocube capsules is available for $119.99.

●     For a five-month supply of Noocube capsules, the price is $179.99.

●     Also, on the official website, you can find different promotional offers:

●     A 20% discount on a month’s supply.

●     A big 46% discount on the three-month supply bottle.

●     A great 60% discount on the six-month supply bottle.

Brain Pill

The Brain Pill is a nootropic solution made to make overall brain health better. It claims to reduce brain fog while making cognitive functions, mental alertness, and overall cognitive performance better. This supplement has natural ingredients, including vitamins, minerals, amino acids, and herbs, and it is in capsule form. More details of these ingredients will follow.

Get Brain Pill now while it’s on sale – limited time only!

Also, we have done a review of the original Brain Pill formula to see if any changes have been made. Now, let’s look at the claimed effect of this product on brain

Benefits:

Better focus: Many people have said that they have more focus when using BrainPill, and we saw the same thing ourselves. With BrainPill, we found that tasks could be done faster, letting us do more in less time. Fast start: While Leading Edge Health, the maker of BrainPill, tells you to be careful about the time for seeing results, we were happy by how fast the effects showed up – in less than a week. It’s important to say that different people may have different experiences, but this fast start was a clear benefit in our review. Price: Brain Pill is only for sale on the official website:

A One-month supply of Brain Pill costs $69.95, plus the shipping fee. A Two-month supply of Brain Pill costs $130.95, plus the shipping fee. A Three-month supply of Brain Pill costs $192.95, plus the shipping fee. A Four-month supply of Brain Pill costs $253.95, plus the shipping fee. A Five-month supply of Brain Pill costs $310.95, plus the shipping fee. A Six-month supply of Brain Pill costs $354.95 and has free shipping in the United States. The Final Conclusion

Many people struggle with sleep problems and ADHD, stopping them from using their full mental power.

In their search to make mental performance better, many choose a prescription medicine called Adderall Australia. Even though it has FDA approval, there are many reports of bad effects.

In these situations, people look for natural options to Adderall Australia, looking to make brain health, cognitive function, and mental energy better while dealing with ADHD.

As a result, we suggest choosing only the best Adderall Australia options in this article to get the lasting benefits of better brain health.

This article is part of a featured content programme.
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(Published 08 December 2023, 12:11 IST)

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Ultimately, biohacking is a personal and individualized approach to health and wellness, and what works for one person may not work for another.

By prioritizing evidence-based practices, reliable scientific data, and careful consideration of potential risks and benefits, individuals can harness the potential of biohacking to optimize their health and well-being.

The global wellness economy is expected to reach $8.5 trillion in the next three years, with the average cost for biohacking and wellness being over $5,300 per year per American.

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'It saved my life,' ADHD, trauma, OCD patients turn to neurofeedback therapy

Posted at 8:18 AM, Apr 05, 2024
and last updated 2024-04-05 08:18:12-04

CUYAHOGA FALLS, Ohio — Cracking the code to wellness is now costing Americans $1.8 trillion annually.

For the average American, that breaks down to more than $5,300 per year.

Those numbers come from the Global Wellness Summit's 2024 trends report.

The report also shows that the global wellness economy, which generated $5.6 trillion in 2022, will continue to surge and reach $8.5 trillion within the next three years.

A driver of those staggering stats is ‘biohacking,’ which is the term for do-it-yourself biology.

It has generated 951 million views on TikTok and over on Google, there's been a 900% increase in searches for ‘biohacking.’

"The way that i like to describe it is using what we know about biology to help us become better versions of ourselves," said Britney Cirillo with Alternative Therapeutics.

‘Biohacking’ can be anything from using a smartwatch to track our heart rate to jumping in an ice bath and neuro-feedback therapy.

The idea behind neuro-feedback therapy is that we can essentially re-train our brain to tackle mental health issues like depression, anxiety, trauma, and OCD, which Emily Dean suffered from for about a decade.

"Was pretty afraid to even leave my house alone. At my worst, I was unable to care for my physical health," said Dean.

Dean ultimately needed to check into the hospital as her mental health declined.

After being discharged, she discovered neurofeedback therapy.

"It completely changed my life," said Dean.

Dean said the sessions at Alternative Therapeutics in Cuyahoga Falls provided relief that medications and traditional therapies could not.

"We're not your average counseling practice," said Cirillo.

Cirillo uses neurofeedback therapy to balance electrical activity in a patient's brain, regulating delta, theta, alpha, and beta levels.

"If any of those brainwaves are being overproduced or underproduced, that will correlate with symptoms that the client is experiencing," said Cirillo.

The goal is to essentially retrain the brain using operant conditioning, a learning process in which voluntary behaviors are rewarded.

"We tell the brain to do a certain thing when it does that certain thing, they're rewarded instantly by that video game that they're playing," Cirillo.

I was so interested in how it works that Cirillo gave me a taste of a typical session.

My goal was to keep the flames of a fire burning bright and the sound of the crackling strong while playing a game on a tablet.

Cirillo was checking to make sure my brain was in an ideal zone.

I only sat there with the tablet for a short time, but a typical therapy session lasts about 20 minutes.

"And so, with more and more practice, the brain starts to recognize what it's supposed to do and it reinforces that pathway, strengthens it to the point that that's their new normal," said Cirillo.

Despite gaining popularity during this ‘biohacking craze,’ neurofeedback therapy is still considered experimental.

"I think it's an interesting phenomenon," said Dr. Robert Lufkin with the USC School of Medicine.

Lufkin said regulating the brain could give people better outcomes when it comes to their mental health.

"I think in my opinion, this can have beneficial effects on an individual," said Lufkin.

Lufkin said regardless of what form of ‘biohacking’ people choose, it's shifting the balance of the doctor-patient relationship.

"It's certainly exploding in recent years, and I think it reflects the fact that all of us as, as patients are taking control of our own health," said Lufkin.

Dean is beyond grateful she gained control.

"Neurofeedback therapy and Alternative Therapeutics saved my life," said Dean.

After completing 20 sessions five years ago, Dean has been able to maintain her progress with a few booster sessions, along with some tools to help her navigate the world.

A world that, for years, Dean navigated with crippling fear.

"Before neurofeedback I was afraid to go to the grocery store alone. Last year, I went to California alone. That is something that I never thought would be possible for me," said Dean.

With insurance companies still considering neurofeedback therapy experimental it is not covered.

However, Cirillo said many of her clients have success when they submit for out of network reimbursement.

On average, people will need about 20 sessions to get the end results they're looking for.

The longevity industry is expected to be worth 600 billion yuan in 2025, with investment in biotech driving the industry forward.

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From the seating arrangements to the glasses on the table, the details are everywhere.
"Aging can be cured" nutrition scholar: long life is not a dream
The United States is aging, with more and more elderly people reaching the age of 65 every day. "Ageing is a disease, a treatable disease," says Serena Poon, a nutritionist and researcher on long-term health.
Serena and her business partner, Harvard geneticist David Sinclair, are on a global tour to educate listeners and potential investors on the concept of healthy longevity.
Until last year, Serena wanted to live to be 120, and now she is reluctant to give specific figures, but is passionate about the future of human life in old age; "aging will become easier to solve than cancer," Hinckler said in her book.
We can treat ageing in our lifetime, "he said.
In recent years, the pursuit of longevity of the gene gold rush has been promoted as a decathlon industry, is expected to be worth 600 billion yuan in 2025.
Health products such as metformin, resveratrol and rapamycin are seen as revolutionary miracles in delaying aging; in the pursuit of a longer and healthier life, the basics of nutrition, exercise, sleep, a lot of biomarkers, emotional health and social engagement are all areas that need to be improved and continuously monitored.
Longevity has developed multiple dimensions in recent years, and for scientists and tech giants, it is a huge, accelerating field of research, the holy grail of “biohacking, ” and a potential treasure trove of biotech wealth.
Longevity has become a buzzword and industry, in part because of huge advances and investment in research, and the pursuit of longevity is a perpetual theme of history, faith and mythology; S. Jay Olshansky, who specializes in aging at the University of Illinois, says promoting anti-aging elixirs is “the second oldest profession in the world ” and the difference is that modern technology is finally keeping up. the pace of this idea.
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Researchers are working to improve biomarkers for healthy aging, and some consider aging a treatable disease.

However, the lack of evidence from clinical trials on anti-aging supplements makes it difficult to support their use for life extension.

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Content: Testing anti-ageing supplements may uncover answer to healthy life

Professor Cynthia Kenyon has called for substances found in red wine and sperm to undergo testing in human trials to figure out how effective they are.

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Clinical trials on anti-ageing supplements may uncover the answer to remaining healthy in later life, an expert has said.

While many supplements are readily available and inexpensive, there is a lack of evidence to show if they are effective, said Professor Cynthia Kenyon, an ageing expert.

Clinical trials may reveal that one supplement, already in circulation, holds the secret to slowing down the biological ageing process, and in turn, age-related diseases like cancer and dementia.

Prof Kenyon, who works for Google subsidiary, Calico Life Sciences, and whose research revolutionised the scientific understanding of ageing, said trials on rapamycin and metformin - two supplements that have been linked to anti-ageing - are needed in particular.

Rapamycin was originally developed as an immunosuppressant for organ transplant patients, while metformin is used controls glucose production in type 2 diabetics.

She also called for other substances found in red wine and sperm to be tested.

"A clinical trial that's large enough to be meaningful costs millions of dollars," Prof Kenyon said. "And so there's no business model for this because if you want a clinical trial with something that's freely available and inexpensive, you can't recoup your cost of the trial.

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"And yet it's an important need for the world because if they work and make you more resilient, not only do these interventions slow down ageing, but they counteract age-related disease also.

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"So you would make people - if they work - resilient and more disease-resistant, and they can be sold to everyone, poor people can be given them."

She added that knowing which supplements work on humans would be "wonderful for the world".

Prof Kenyon called for the World Health Organisation (WHO), governments, non-profit groups and philanthropists to get together and start human trials.

"We don't know if any of them will work, but you find out," she said.

Some clinical trials have shown positive results for metformin, sirolimus, and resveratrol in aging indications, but more research is needed to confirm their effectiveness.

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Content: BioWorld by Clarivate Explores the Concept of Extending Human Lifespan in New Report

Special report on aging investigates the latest science, key biological drivers and companies driving the development of potential “Fountain of Youth” candidate drugs

LONDON, July 20, 2022 /PRNewswire/ — BioWorld published by Clarivate Plc (NYSE:CLVT), a global leader in providing trusted information and insights to accelerate the pace of innovation, today announced the release of a new report, Extending the Human Lifespan, which examines the science around extending our time on earth alongside our quality of life. The report provides an in-depth analysis of the latest science, the key biological drivers that can be targeted pharmacologically and the companies developing these potential “Fountain of Youth” candidate drugs.

According to United Nations data, the global population of people 65 and older rose 468% between 1950 and 2020. This dramatic increase in population reinforces the goals of researchers and companies to develop ways for people to live longer in a healthy way. Biopharmaceutical research can positively impact the prevention of diseases that come with aging, thereby extending life for the masses. Many forward-thinking scientists are focusing on the biology of aging. While no drug will halt the inevitable process of getting older each year, anti-aging drugs could simultaneously reduce the risk of multiple age-related illnesses, such as Alzheimer’s, cataracts, strokes and other diseases of aging. In addition, equitable access to drugs and therapies tackling aging could reduce health care costs in a major way and improve quality of life.

The BioWorld special report explores these scientific advances in a four-part series paired with the latest episode of BioWorld Insider Podcast, Extending the Human Lifespan. Key report findings include:

  • There are currently 139 trials testing seven existing drugs targeting aging, some of which reliably extend lifespan in one or both sexes by up to 30%, including metformin, sirolimus, resveratrol, alendronic acid, denosumab, donepezil and zoledronic acid. But the number of therapeutics being studied to combat aging is much bigger.
  • Cortellis Clinical Trials Intelligence™ lists another 106 trials of those therapies in clinical development for everything from osteoporosis to Alzheimer’s disease. There are dozens of other therapies in development as well, with 26 current clinical trials for end-stage renal disease, liver cirrhosis, Alzheimer’s disease, cancers, infectious diseases and osteoarthritis and other aging conditions.
  • According to BioWorld data, from 2020 through early July 2022, $1.95 billion was raised through 38 financings for private aging disease companies. Cortellis Clinical Trials Intelligence lists 16 current clinical trials focused on metformin, sirolimus and resveratrol – three therapies that have shown positive results in aging indications. Expanding to recently completed trials, the list climbs to 33.
  •  There is a clear risk of anti-aging approaches exacerbating gender differences in health span. The male body has been used as biology’s baseline for much of the last century. The majority of what is known about aging comes from the study of males, with the female sex being understudied.
  • The overlap between science and commerce can be problematic for several reasons. It may become hard to distinguish consumer marketing from solid evidence-backed science, especially as it relates to research that extends lifespans.
  • In the biopharma industry, sirtuins have highlighted some of the challenges in translating aging research. Research in the early 2000’s suggested that activation of sirtuins could extend lifespan, but the idea of getting enough resveratrol to boost lifespan through the diet in forms such as red wine was, ironically, short-lived.

Lynn Yoffee, Publisher, BioWorld said: “Researchers in the life sciences are pioneering new work related to our existence. In order to ensure society and patients can benefit from therapies old and new, it is critical that we understand the implications of these discoveries. The new BioWorld report delves into whether research can validate if we can live longer in a healthy way, if therapies can both extend life and reduce the risk of multiple age-related illnesses, whether equitable access to these therapies is possible and more.”

For more exclusive, in-depth analysis of the concept of extending lifespan, read the multipart special report here.

About BioWorld

With writers and editors stationed around the globe, BioWorld published by Clarivate, reports the breaking news – and provides key perspective on hundreds of therapeutics and devices in development, the companies behind those candidates, the business development transactions that evolve the markets, and the regulatory hurdles that both challenge and guard the processes. BioWorld has a long tradition of excellence in journalism. Collectively, the news services have been honored with 63 awards dating back to 1998, including 15 for its daily news services.

Join the conversation and mention BioWorld on Twitter and Clarivate for Life Sciences & Healthcare on Twitter and LinkedIn.

About Clarivate

Clarivate™ is a global leader in providing solutions to accelerate the pace of innovation. Our bold mission is to help customers solve some of the world’s most complex problems by providing actionable information and insights that reduce the time from new ideas to life-changing inventions in the areas of Academia & Government, Life Sciences & Healthcare, Professional Services and Consumer Goods, Manufacturing & Technology. We help customers discover, protect and commercialize their inventions using our trusted subscription and technology-based solutions coupled with deep domain expertise. For more information, please visit clarivate.com.

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Director, External Communications, Life Sciences & Healthcare
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The use of supplements like metformin, resveratrol, and rapamycin for life extension is not approved by the FDA, and their effects on human longevity are unconfirmed.

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Rapamycin: From Transplant Drug to Anti-Aging Phenomenon, Public Embraces Experimental Use

Rapamycin, initially for transplant patients, emerges as a hopeful anti-aging solution. Its journey reflects the complex interplay between scientific promise and regulatory hurdles.

Sakchi Khandelwal
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Amid growing fascination with the potential to slow aging, rapamycin, a drug originally designed for transplant patients, is now gaining traction as an experimental anti-aging treatment. Despite its proven efficacy in extending the lifespans of various animals, its effects on human longevity remain unconfirmed. David Sandler, a 77-year-old retired accountant, joins a daring cohort, self-administering rapamycin, intrigued by its promise to fend off age-related diseases. His story echoes a broader trend where, fueled by celebrity doctors and longevity researchers, the drug's off-label use for aging is proliferating, despite the absence of FDA approval for this purpose.

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The Science Behind Rapamycin

Rapamycin works by interfering with a cellular communication system that regulates growth and survival, encouraging cells to purge accumulated waste and operate more efficiently. This mechanism has led to significant lifespan extensions in animal studies. However, the FDA does not recognize aging as a disease, complicating the path to potential approval for longevity purposes. With rapamycin's patent in the public domain, the economic incentive for costly human trials is minimal, leaving its anti-aging benefits largely speculative.

Rising Popularity and Controversy

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Despite these hurdles, over two dozen medical practices in the U.S. now prescribe rapamycin for aging, and telehealth platforms have expanded its accessibility. Dr. Alan Green has treated nearly 1,500 patients with rapamycin since 2017, hailing it as a pivotal medical breakthrough. However, the drug's reception in the scientific community is mixed. While some see its potential for human lifespan extension, others caution against unknown optimal dosages and potential side effects like insulin resistance and increased infection susceptibility. The debate underscores the complex balance between rapamycin's promising anti-aging effects and its safety profile.

Rapamycin's Place in Longevity Medicine

The enthusiasm for rapamycin parallels the burgeoning field of longevity medicine, with entities like Altos Labs and the Hevolution Foundation investing billions into aging research. Physicians like Peter Attia and public figures such as Andrew Huberman have further popularized the drug among health-conscious communities. Discovered in the soil of Easter Island and FDA-approved in 1999, rapamycin's journey from an organ transplant drug to a potential longevity miracle encapsulates the evolving quest for extended healthspan. Yet, as the narrative unfolds, the promise of rapamycin as a life-extending agent remains a topic of spirited debate and hopeful anticipation.

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Biohacking enthusiasts often use various methods, including nutrition, physical activity, supplement intake, and medical screenings, to achieve "self-optimization" and improve their health and well-being.

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Your Dog Will Have An Anti-Aging Drug Before You Do

Clinical trials on humans could take decades — long enough for the study subjects to live out the rest of their lives. That's where man's best friend comes in.

Growing old together (maybe).

Before we have an anti-aging drug for humans, we’re likely to have one for dogs. Multiple clinical trials are currently underway to test potential anti-aging compounds on dogs, since our best friends have become a popular animal model for human aging. Fido also represents a potentially huge market.

The science could benefit both species, but premature claims are already causing a credibility problem.

Recently, Harvard University biologist David Sinclair started marketing life-extension supplements for dogs, touting unpublished clinical trial data that others in the field found completely unconvincing. Earlier this month Sinclair, who didn’t respond to requests for an interview, changed the wording of a press release, which originally promised the chewy treats would “reverse aging.” Now it says they reverse the effects of age-related decline.

Sinclair’s trial used dog owners’ subjective assessments of cognitive changes in their older pets — and other scientists say the trials don’t show a consistent enough effect even for this more modest claim. (Sinclair became famous in the 1990s for some highly publicized papers tying aging to proteins called sirtuins — an idea that led to the now widely disputed belief that red wine has anti-aging properties.)

While the FDA is authorized to regulate veterinary drugs, it doesn’t approve supplements for pets or people, so these can be sold without going through tests for safety and efficacy.

Whether anti-aging supplements for dogs work or not, there’s likely to be demand, said Arthur Caplan, a professor of ethics at New York University. In the past, desperate dog owners have had their dead or dying dogs cloned — hoping the clone would be essentially a reincarnation of their dead pet.

Some researchers who study aging fear that the spectacle of a high-level professor hawking dog longevity supplements will further tarnish the reputation of a field already dragged down by self-proclaimed experts pushing fad diets and unproven anti-aging treatments for people.

There’s a lot to gain from a better scientific understanding of aging. Getting older is a risk factor for all the major killer diseases — heart disease, cancer and even severe Covid. And in the US, the ranks of people over 70 will swell within the coming years, creating a vast increase in the number of people suffering from dementia or other age-related problems.

But scientists don’t yet agree on what causes aging or what approach would work best to slow it down. While wear and tear will eventually affect all living things, some organisms live many times longer than others, even among closely related species. Some researchers think an animal’s aging rate is controlled by certain genes. Other experts cite the shrinking of the caps on the end of or chromosomes, called telomers. Others blame the degeneration of the packaging around our DNA — so-called epigenetic markers, which can activate or suppress certain genes. Some scholars blame damage caused by chronic inflammation. Still others, the buildup of cellular waste products.

Some of these possible mechanisms of aging can be altered with drugs in a way that endows worms, fruit flies and mice with longer lives. Which drugs should be tried in humans? Clinical trials to test their effects on longevity in people could take decades — long enough for the study subjects to live out the rest of their lives.

One way to identify the more promising candidates would be to see which ones also work in dogs. Dogs are long-lived enough to serve as a better model for human aging than mice, but short-lived enough that treatment can be tested in a few years.

Matt Kaeberlein, CEO of Optispan and an affiliate professor at the University of Washington, was among the most vocal critics of Sinclair’s dog longevity claims. He’s also in competition as co-director of The Dog Aging Project. That project involves collecting data on thousands of dogs as well as conducting a dog clinical trial with a drug called Rapamycin. It’s currently approved for people who’ve had organ transplants. At high doses, it causes mouth sores and other nasty side effects, he admits, but can extend the lives of mice and — at low doses — might do the same in dogs or humans.

A group of biohacker types is already taking Rapamycin off-label in the hope of life-extension, he said. He’s trying to get data from them, messy as it is, because there might be useable information there. (Caplan, the NYU ethicist, says he thinks it’s unethical for doctors to prescribe this drug off-label for longevity.)

Kaeberlein said the biological data they’re collecting from all those thousands of dogs could lead to an explanation for the fact that big dogs don’t live as long as small ones. “If you compare a Great Dane to a chihuahua on average, it’s at least a twofold difference in life expectancy,” he said.

But his project might be a victim of the field’s wider credibility problem. It had been funded by the National Institutes of Health, but he and his colleagues learned recently that a five-year grant established in 2018 and extended one year probably won’t be renewed. He’s now working to get private money.

Charles Brenner, a biochemist at the City of Hope National Medical Center in Los Angeles, is another vocal critic of Sinclair’s claims regarding dogs and humans. (Like most researchers on the forefront of aging, he has his own supplement ties as chief scientific advisor of a bioscience company called ChromaDex.)

Brenner is also skeptical of those who claim various treatments or drugs can reverse a person’s “biological age” as calculated through proxies measured in blood — including telomeres and epigenetic markers. None of these measure aging as well as walking speed, he said.

When I asked him about the Rapamycin study in dogs, he said it’s “worth a try” because the trial measures actual lifespan rather than some proxy. But he isn’t betting on this particular drug. He’s more optimistic about work done by a company called Loyal, profiled in 2021 by Bloomberg Businessweek.

Brenner says while Loyal has been secretive about the drug, he thinks what they’re now testing inhibits the production or action of growth hormone. Growth hormone, he said, is connected to the faster aging they see in larger dogs compared to smaller ones.

There’s promise in studying how and why animals age — not just dogs but clams that can live to 500, rockfish that survive until 200 and whales that reach 80. Once scientists understand the mechanisms of aging, they’ll be much better able to find ways to help us — and our furry friends — live longer and healthier lives.

But first, they need investors and the public to take them seriously.

More From F.D. Flam at Bloomberg Opinion:

  • AI Is Trying to Predict Your Death. It’s Not as Scary as It Sounds.
  • Whales Are Helping Solve the Mystery of Menopause
  • The US Needs a 9/11 Commission for Covid

This column does not necessarily reflect the opinion of the editorial board or Bloomberg LP and its owners.

F.D. Flam is a Bloomberg Opinion columnist covering science. She is host of the “Follow the Science” podcast.

More stories like this are available on bloomberg.com/opinion

©2024 Bloomberg L.P.

Metformin, resveratrol, and rapamycin are popular supplements used by biohackers for life extension, with some studies suggesting they may extend lifespan by 10-20%.

Title:

Content: NEWS
Coronavirus
Diseases and medicines
Science
Traditional medicine
HLS
Scientists: in the future, a person will be able to live 20% longer
Scientists from the National Institute of Aging USA conducted research and found out how to extend life by 10-20% and prevent aging.
This is reported by CNBCTV.
Photo: depositphotos.comdepositphotos.com
One way was to take the drugs metformin and rapamycin.
These drugs have been tested on animals and have shown good results, they are aimed at molecular processes associated with cell aging.
Also, experts noted that the so-called synolytics literally remove from the body senescent cells that accumulate in tissues, but do not die.
So far, unfortunately, there are a number of technical and moral and ethical obstacles to the fact that today these methods can be tried on a wide range of people.
Since the U.S. Food and Drug Administration does not consider aging to be a disease that should be treated, it is very difficult to obtain permission to use such drugs.
Now scientists have to find out whether their discovered ways to prolong life have a positive effect on health.

However, the use of these supplements can also have potential risks and side effects, such as headaches, drowsiness, and anxiety.

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It is essential to approach biohacking with a critical and nuanced perspective, recognizing both its potential benefits and limitations, and prioritizing evidence-based practices and reliable scientific data.

By doing so, individuals can harness the potential of biohacking to optimize their health and well-being, and improve their overall quality of life.

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